Sentences with phrase «identify particular cell»
Conventional flow cytometry is a powerful technique for measuring cell phenotype and function, but it relies on fluorescent stains, or labels, to identify particular cell subpopulations.
https://www.broadinstitute.org/ Not exact matches
Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context.
In particular, the study suggests that two miRNAs — miR - 4516 and miR - 601 — in tumor cells along with Gleason score and lymph node status may help identify patients who might experience rising PSA after they've been treated with radiation therapy.
The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.
A study led by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified an abnormal metabolic pathway that drives cancer - cell growth in a particular glioblastoma subtype.
The current study identified a new role for a particular group of proteins, known as RFX transcription factors, in the development and survival of the hair cells.
By identifying the genes in any given taste cell, scientists can pinpoint the unique molecular components needed for that cell to carry out its particular function.
This tool, described in a paper published April 18 in Nature Biotechnology, is designed to help researchers identify groups of genetic variations that together associate with a particular way cancer cells get activated, or how they respond to certain treatments.
... We essentially start with those cell lines, try to identify patterns between the mutational status of the cell line and the response to a particular drug, either in terms of the ability of the drug to inhibit a pathway.
The study identified several other potential colitis genes, he added, and this particular one's effect on the barrier cells» energy requirements suggests a new category of mutations with the potential to cause IBD.
The expression of specific genes in a particular root cell determine its fate — the zone in which it will function, Subramanian explained, so he is identifying which micro-RNAs direct gene expression to achieve this differentiation.
They identified signals that white blood cells use to control their behaviour, then one by one disabled those signals — discovering that one particular molecule called ERK5 could be manipulated to encourage white blood cells either to throw out pathogens better or to keep them inside and try to kill them for longer.
In particular, the research identified several genes regulated by methylation in the egg that are involved in cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo development.
They also identified targets for potential therapies: bolstering levels of either a particular chaperone or a growth factor in brain cells can protect against the toxic effects of misfolded proteins.
To take a finding in basic research, such as identifying a mutant protein that drives a particular cancer, and develop a drug that inactivates the protein and performs well in cells in the lab and in animal models can take years, if not decades.
We developed and implemented such a nomenclature for the European human pluripotent stem cell registry (hPSCreg), which needs to: 1) unambiguously identify a registered cell line; 2) allow tracing of subclones of a particular line; and 3) enable the assignment of different lines to a specific donor origin.
Luckily, different cell types tend to have different things on their surfaces, which play particular parts in their specialized roles in the tissue, so it is a matter of identifying and targeting cell - surface markers that are specific to these abnormal cell types.
The research, published in Cell Metabolism, identified the role of a particular protein, IL - 6, released by cancer cells even before cachexia manifests.
In each case there is interest in obtaining comprehensive, accurate data for particular cell types and in identifying patterns of variation within the data.
These include pre-anesthetic physical examinations to identify any particular concerns, pre-anesthetic bloodwork to ensure proper cell counts and organ function, preanesthetic chest radiographs in those patients with heart disease... all of these are geared towards identifying risk.