Sentences with phrase «identify potential therapeutic targets»
However, a great deal of basic research is still required to understand the molecular bases of rare diseases and identify potential therapeutic targets.
http://kidsgenomics.org/
«Through the dedicated work of translational scientists, we are beginning to uncover the mechanisms that unleash the symptoms of celiac disease and identify potential therapeutic targets.»
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»
The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.
They hope to identify a potential therapeutic target for Zika virus.
Despite this generally well - accepted idea for how high eye pressure may affect RGC axons, scientists still do not understand the injury mechanisms involved in sufficient detail to begin identifying potential therapeutic targets.
Not exact matches
Researchers hope the organoids will be better than lab animals or cells growing in culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»
It has the potential to identify novel, rare mutations that are «actionable» therapeutic targets,» Chinnaiyan added.
«We only used tungsten in «proof - of - concept» experiments to identify a potential molecular target, and we are still far from turning this basic discovery into a therapeutic treatment in patients,» Dr. Winter said.
«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.»
Therefore identifying the essential, tissue - specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.
«New color blindness cause identified: Finding suggests potential therapeutic targets.»
«Potential therapeutic target for wound - healing, cancer identified.»
The overall goal of the TGen study was to look at genomic and epigenomic events to understand the causes of breast cancer brain metastatic lesions, and identify potential new therapeutic targets.
Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
«Given the therapeutic potential of the nSMase target, we're now working closely with Drs. Barbara Slusher, Camilo Rojas, Ajit Thomas and colleagues at the Johns Hopkins Drug Discovery facility to identify potent inhibitors of the nSMase enzyme which can be developed for clinical use,» says Haughey.
The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.
Previous investigations had identified hUPF1 as a potential therapeutic target for ALS, but it was unclear how this protein prevented cell death.
Gladstone scientists identify inflammatory pathways as a potential therapeutic target for frontotemporal dementia
PrediXcan has the potential to identify gene targets for therapeutic applications faster and with greater accuracy than traditional methods.
This project has the potential to uncover clinically relevant mechanisms of cellular senescence in fibrosing ILDs and identify new therapeutic targets
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5
Together, these data define METTL3 as a regulator of a chromatin - based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.
Temporal specimens collected and tested during the course of treatment identify the loss or elimination of driver mutations as well as emergence or re-emergence of new clones and new potential therapeutic targets.