Sentences with phrase «identify potential therapies»

His research aims to understand mechanisms of resistance to targeted therapies in cancer and identify potential therapies to overcome that resistance.

Dr. Chen's previous work focused on retinal vascular biology to understand the causes and identify potential therapies to treat pathologic blood vessel growth in eye diseases, including the wet form of AMD.

With Helmsley funding, CCFA's research consortium is now looking to identify potential therapies for development by pharmaceutical companies while also conducting a rigorous investigation of the effect of diet on the microbiome and how that might allow patients to alter the course of their illness without taking medications.

«Likely biological link found between Zika virus, microcephaly: Discovery with lab - grown stem cells could be used to identify potential therapies.»

WGS currently requires significantly more manual analysis, so combining this method with artificial intelligence could help doctors identify potential therapies from WGS for more patients in less time.

The whole genome and RNA sequencing data were analyzed by a team of bioinformaticians and oncologists at the NYGC as well as a beta version of IBM Watson for Genomics, an automated system for prioritizing somatic variants and identifying potential therapies.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

MMRF and Memorial Sloan Kettering to launch a new clinical trial to identify potential genomic markers linked to achieving and maintaining deep response to therapy Read More

«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»

The study also reinforces the potential value of brain scans for identifying and understanding schizophrenia in individual patients, for finding promising new therapeutic approaches, and for helping clinicians track a patient's progress during therapy.

«This first step in the characterization of the phages already present within the bladder has the potential to identify candidates for subsequent phage therapy clinical studies for urinary symptom treatment.»

The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.

«Potential targeted therapy for lung cancer identified using fly model.»

Despite this new direction for identifying targets for pharmaceutical interventions against RP, the researchers underscore that gene therapy still has great potential and possible benefits, and they are actively pursuing efforts with this approach for several forms of RP.

«By identifying this unexpected connection between DIXDC1 and LKB1 in certain tumors, we have expanded the potential patient population that may be good candidates for these therapies,» adds Goodwin.

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

Analyzing more than 120 million patient records and identifying trends of co-occurrence among hundreds of diseases, they created a unique genetic map that has the potential to guide researchers and clinicians in diagnosing, identifying risk factors for and someday developing therapies against complex diseases.

Professor Moffatt said: «The genes we identified represent new potential drug targets for allergic diseases as well as biomarkers that may predict which patients will respond to existing expensive therapies.»

«This one - two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene's lab has been able to identify a potential new therapy for blocking the disease's progression and improving on current antiretroviral medications.»

While the researchers can not yet point to a potential therapeutic application of their findings, identifying genetic changes that underlie MND is the first step in finding ways to manipulate these changes using gene therapy.

The results also indicate the KRAS - variant's potential to identify people who will respond differently to therapies that depend on the immune response.

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments.

«We've identified what leads to this difference in vision loss, and that suggests novel potential therapies to treat this serious medical problem in children.

And in the clinic, pupils may help diagnose or identify people at risk for mental illnesses, such as anxiety, or the effectiveness of potential therapies.

Selectively expressed on GBM and absent on surrounding brain tissue, the interleukin - 13 receptor α chain variant 2 (IL13Rα2) was identified as a potential target for therapy for GBM two decades ago.

They also identified targets for potential therapies: bolstering levels of either a particular chaperone or a growth factor in brain cells can protect against the toxic effects of misfolded proteins.

The strategy developed by research teams and development of I - Stem aims to identify innovative therapies applicable to rare genetic diseases based on exploring the potential offered by human pluripotent stem cells.

Michigan Medicine and MedImmune, the global biologics research and development arm of AstraZeneca (NYSE: AZN), have entered into a three - year research alliance to identify potential new therapies for the prevention and treatment of diabetes, obesity and related metabolic disorders.

Additional insight into the biology of ER - positive breast cancers, particularly the higher risk luminal B cancers, could aid in identifying potential targets and new, effective therapies.

Routine molecular profiling for BRAF and KIT is recommended and may identify potential targeted therapy options.

«Contrary to the impression created by the concluding sentences in the summary and discussion sections, this study does not identify a potential probiotic therapy for people with autism and gastrointestinal problems.

The researchers plan to use the mouse models of CAVD to test several potential drug therapies they identified, in the hopes of discovering the first medical treatment for the disease.

RD - Connect bioinformatic tools In addition, RD - Connect has developed several bioinformatic tools to help researchers analyse omics data and identify targets for potential therapies.

While stem cell research has enormous potential to yield new therapies for other diseases, in most cases, years of research will be required to identify the diseases that can benefit from stem cell treatments and to figure out how stem cells can be used safely and effectively in those contexts.

After developing and optimizing assays in - house, Gladstone scientists can transfer these assays to the SMDC or other external facilities to perform high - throughput screening with large compound libraries to identify potential drugs that may lead to therapies.

She's hoping to better understand the molecules in order to identify potential biomarkers of the disease, its status, and what therapies are effective.

Numerous international publications testify to the research group's commitment to identifying metabolic and molecular pathways as potential targets for innovative therapies that combine nutraceutical intervention and physical exercise, for the prevention and treatment of insulin resistance, of diabetes and associated complications.

data and identify targets for potential therapies.

By identifying novel molecular targets and potential new drugs, this powerful technological structure will contribute significantly to groundbreaking research towards the development of new anti-cancer therapies.

For potential hESC - based neural replacement therapy, it would be useful to identify compounds that are selectively toxic to proliferating NSCs and not terminally differentiated postmitotic neurons.

This approach has the potential to identify individualized optimal therapy whilst providing cost and time effective options to relevant stakeholders for better health - care delivery.

Their Therapeutic Order ™, identifies the order in which therapies should be applied to provide the greatest benefit with the least potential for damage.

Taken together, these findings support a gut - microbiome - brain connection in ASD and identify a potential probiotic therapy for GI and behavioral symptoms of autism.»

Nutritional therapy practitioners use a wide range of tools to assess and identify potential nutritional imbalances and understand how these may contribute to an individual's symptoms and health concerns.

The next step in this project will be two-fold: 1) To define a genetic test to identify potential affected dogs and, 2) To identify new therapies for dogs affected with osteo

In Maximize Your Coaching Effectiveness with Acceptance and Commitment Therapy, you'll learn to help your coaching clients harness these powerful psychological techniques to identify their passions, set values - based professional and personal goals, and realize their full potential.

The study questions concluded with respondents» feedback identifying potential barriers to treatment of using concurrent group therapy as a treatment modality.

In therapy, potential triggers or danger zones that may facilitate addictive behavior can also be identified and a plan to avoid these triggers developed.

Attending couples therapy before marriage will help you and your partner identify potential problems that will come up in the future.

Going to pre-marital therapy can help identify potential problem areas in your marriage before they even become an issue.