Sentences with phrase «identify signaling proteins»

They identified a signalling protein that was frequently mutated in more aggressive subsets of the disease.

Not exact matches

The vast majority of the thousands of potential membrane protein - signaling protein interactions they found had never before been identified.

It is expected that the molecular mechanisms underlying the inhibition of interferon signal transduction by C proteins would then be fully identified.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

Among the targets identified by Dr. Laviolette are receptors and other proteins involved in signalling of a neurotransmitter called dopamine.

Researchers at Bonn University, together with collaborators from the Sainsbury Laboratory in Norwich, identified a protein that allows plants to recognize a chemical signal from the worm and initiate immune responses against the invaders.

«This is the first time that this specific protein - protein signaling complex has been identified in GBM, and it gives us a new potential target for drug development,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.

The team also identified genes that had not been previously linked to ASD, but are heavily involved in numerous protein interactions and signaling pathways.

It was this calcium signal that researchers identified as the trigger of a genetic programme that controls the production of «memory proteins.»

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

His team uncovered an extensive network of redox activity, identifying 176 proteins that are sensitive to signaling in this manner.

By identifying the molecular signals emitted through the soil by friendly fungi, the protein enables a plant to «roll out the red carpet» for cell colonisation by the fungi, and all the survival advantages this mutually - beneficial relationship brings — the fungi feeds minerals such as phosphate into plant cells in return for sugar extraction.

By analyzing a dataset of human immune cells stimulated with interferon — a signaling protein created in response to pathogens or tumor cells — the team could precisely identify which genes were switched on in each of 13 responding cell types.

Researchers have identified a protein that controls how breast cancer cells spread around the body, according to a Cancer Research UK - funded study published in Science Signaling.

«But we have to further study the functions of this histone, identify the other proteins with which it is associated, and determine the enzymes that modify it and why and the cell signalling pathways involved,» explain the scientists.

The team led by Rory Fisher, Ph.D., professor of pharmacology in the UI Carver College of Medicine, has identified a protein called RGS6 (regulator of G protein signaling 6) that acts through two separate mechanisms to control alcohol - seeking behavior and alcohol - induced cell death in heart, liver, and other organs.

Researchers identified that a protein, called PAQR11, inside the «cellular post office», receives a signal from another protein, called Zeb1; the communication between the two proteins prompts the transport of membrane sacks inside the Golgi.

Using cell culture assays and genetically modified mice, we identified a number of signaling proteins that participate in muscle plasticity.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

The research described in this essay focused on understanding this pathway by identifying protein factors that form a lysosome - based signaling platform that positively and negatively regulates the function of the Rags.

Her previous work identified the scaffold protein p62 as a critical component of the mTORC1 nutrient - sensing signaling complex.

«Most of the signals that people are working with and identifying right now are the most abundant signals — the main effector proteins,» says Klemke.

Using viral transfection methods, Dr Banker has identified some of the signals that target integral membrane proteins to axons and dendrites and are using this approach to study targeting at early stages in the development of polarity.

In the cytoplasm, lethal toxin is a zinc metalloprotease that cleaves a number of identified proteins, including members of mitogen - activated protein kinase (MAPK) signaling pathways [33] and the inflammasome - activating sensor NLRP1B [34].

A single mutation was identified in the protein non-receptor tyrosine kinase 2 (TYK2), which promotes cytokine signalling during infection.

In the first paper, utilizing genomic analysis of nearly 8,500 Icelandic and Dutch participants, the deCODE team identified a novel, tightly - linked pair of single - letter variants (SNPs) near the ASIP (agouti signaling protein) gene on chromosome 20 that greatly increase the likelihood of an individual being prone to freckles and sunburn.

Based on these sources, we identify 497 genes with possible immune function in Nasonia (Table S1), including 75 encoding effectors (AMPs, proteins in the prophenoloxidase cascade, transferrins, and peroxidases), 96 encoding recognition proteins (including PGRPs, TEPs, Nimrod - like proteins, and numerous lectins), 101 encoding signaling proteins, and 225 encoding proteases or protease inhibitors.

We are using biochemistry and genetics to identify the proteins that enable neurite - specific neuropeptide localization and using cell - type - specific genetic manipulations to disable that machinery and thereby probe the behavioral function of extra-synaptic peptide signaling in specific circuits.

The scientific goal of the Cancer Biology Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells.

We used a bioninformatics analysis to identify that miR - 181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP - induced neurite growth.

We also found that the SRC and ABL non-receptor tyrosine kinases and the SHEP1 scaffolding protein are binding partners of the Eph receptors, and we identified signaling connections between Eph receptors and integrins.

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

Briefly, full - length secreted molecules and the entire ectodomains of membrane - embedded proteins were identified using transmembrane [28], GPI - anchor [29], and signal peptide [30] prediction software.

Finally, we identified several signaling pathways which may mediate this phosphorylation and act in combination to regulate Oct4 transcriptional activity and protein stability.

As an example, the CDK5 signaling pathway, was found to be significantly enriched (p = 0.00009) for proteins identified only in the pooled CFS proteome.

Researchers identify the molecular structure of the GATOR1 protein complex, which regulates growth signals in human cells, using cryo - electron microscopy.

With similar precision, Professor Bargmann has also identified many of the intracellular signalling pathways in C. elegans that relay information from cell surface odorant receptors (G protein - coupled receptors) to the interior of each sensory neuron.

The successful candidate will receive extensive training on proteomics - based discovery (secretome proteomics to identify cytokines important in different children's cancers, protein expression profiling of subcellular fractions and organelles, and interactome proteomics to identify novel protein — protein interactions) and follow - up of proteomic findings (molecular cell biological characterization of protein functions and signaling).

Even when the product label identifies the product simply as colloidal silver and never mentions the word protein, this indicator will signal the presence of a protein binder.

Use Proteomics techniques to identify, signaling pathways, protein interactions, protein modifications.