Sentences with phrase «identify smaller gene»

The software, called DECoN, accurately and quickly detects changes in copy number of blocks of DNA called exons, by analysing sequencing data already generated to identify smaller gene changes.

Not exact matches

To identify gene variants associated with musical aptitude, Irma Järvelä at the University of Helsinki, Finland, and colleagues analysed the genomes of 767 people assessed for their ability to detect small differences between the pitch and duration of a sound, and musical pattern.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

A small percentage of ash trees in Denmark show some resistance to the fungus and the reference genome is the first step towards identifying the genes that confer this resistance.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclasts.

Specifically, Toni Gabaldón's group at the Centre for Genomic Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species.

2006 Shinya Yamanaka identifies and activates a small number of mouse genes in the cells of connective tissue, showing they can be reprogrammed to behave like immature stem cells.

«I saw a relatively small deletion in the X chromosome, identified as Xp11.22; it had only a few genes in it.

In order to identify genes specific for the sensory neurons of Aplysia, a miniaturized differential screening method based on the polymerase chain reaction and applicable to small amounts of tissue was used.

The team also identified genes associated with the mammoth body plan, such as skull shape, small ears and short tails.

Genes linked to physical traits such as skull shape, small ears and short tails were also identified.

«Industry giants like Google, Microsoft and Yahoo are spending tens of billions of dollars a year on acquiring smaller firms for market entrance, strategic intellectual property and talented employees, but face a real challenge identifying companies with the right products or technology in the vast startup universe,» said Gene Moo Lee, UTA assistant professor of Information Systems and Operations Management.

A small set of maternal genes have been identified that are required for these activities.

To gain access to the gene - containing portion of the barley genome at high resolution, Close and his team identified and sequenced 15,622 BACs or bacterial artificial chromosomes — small fragments of the barley DNA linked to other DNA to constitute a circular molecule that can replicate and be propagated inside an E. coli bacterial cell, enabling researchers to produce copies of each BAC for DNA sequencing one small piece of the barley genome at a time.

Genetic factors are clearly indicated as evidenced by dominant mutations in three different genes have been identified that account for the small number of cases of familial, early - onset AD.

On page 386, scientists identify a version of a gene that plays a small but significant role in whether or not people get depressed in response to life stresses.

Previously, genetic counselors tested a small number of genes sequentially based on family profile and tumor analysis until the culprit was identified.

Here, they identified a small molecule, SMARt - 420, that interacts with a secondary gene, which in turn stimulates expression of EthA.

A year ago we started thinking, why don't we select a single family with an interesting disease and see whether studying a smaller group of related individuals makes it possible to identify the genes involved in that disease.

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail - safe mechanism that may protect us from cancer.

The researchers also determined that many of the 18 newly identified autism genes affect the operation of a small subset of biological pathways in the brain.

A dual yeast and human stem cell discovery platform for Parkinson's disease: Investigations in simple baker's yeast cells brought to light abnormalities in Parkinson's patient neurons and identified genes and small molecules that correct them.

It was while he was working on his doctoral project, wing formation in fruit flies, that a discovery made by other investigators in the lab — of the first microRNA (a small RNA important in the regulation of gene expression) identified in the fly — captured his attention and has held it ever since.

Identified first in the Altieri laboratory in 1997, and the source of intense investigation since then with currently 5,000 citations in PubMed, survivin is the smallest member of the IAP gene family.

Although previous studies have identified common somatic mutations in lung cancers, they primarily focused on a small set of genes

Challenged to identify the biological context in which these genes act, the researchers set out to provide the necessary basis for the next steps of small molecule discovery and the development of early stage therapeutics.

Lead author Corina Greven says: «The specific genes involved in academic self - confidence remain to be identified, but we expect them to be many genes of small effect size, and their effects will be probabilistic rather than deterministic.

A small number of these studies have identified individual genes that confer lower fitness when in a foreign or admixed genetic background [3]--[6].

«Scientists can now, at the click of a button and at a single online location, rapidly identify the biological and structural characteristics of an actual or potential drug target, find the genes and proteins that it interacts with, assess its structural druggability and identify any small molecule chemical inhibitors.

Indeed out of hundreds of male or female fertility genes identified in diverse organisms, only a very small number of them are implicated specifically in reproduction in more than one lineage.

They identified more than 33,000 protein - coding genes, placing the octopus genome at slightly smaller in size, but with more genes, than a human genome.

The team identified 85 small molecules that increased noise without changing average GFP gene expression levels.

RhoH is a newly identified hematopoietic small G protein, originally cloned as one of the genes frequently disrupted in diffuse large B cell lymphoma (1, 2).

When dealing with common breeds involving large, diverse gene pools, identified carriers can be eliminated with small risk of adversely narrowing the gene pool.

In breeds with small gene pools, as is the case with many pure breeds, elimination of identified carriers may not be the best strategy, as genetic diversity would become dangerously compromised.

crd1 / rcd1b Test: A small deletion in PDE6B gene has been identified that is associated with the rcd1b disease in the American Staffordshire Terrier breed (2).

A smaller 31 Kb region containing an overlapping homozygous haplotype that contains a single gene, THBS2, was identified within affected breeds (Figure 5).