To avoid such perturbations, researchers have developed a computer program that can distinguish between cell types and
identify subcellular structures, among other features — all without the fluorescent probes our human eyes rely on.
The article describes a novel image - based screen to
identify compounds that increase SMN protein levels in
subcellular compartments of intact cells.
The successful candidate will receive extensive training on proteomics - based discovery (secretome proteomics to
identify cytokines important in different children's cancers, protein expression profiling of
subcellular fractions and organelles, and interactome proteomics to
identify novel protein — protein interactions) and follow - up of proteomic findings (molecular cell biological characterization of protein functions and signaling).