«His lab was the first to
identify yeast genes that regulate autophagy.
Not exact matches
Here's how it works: Scientists
identify the desired
genes in a plant or animal and insert them into a host such as
yeast.
Yoshinori Ohsumi, the most recent prizewinner, used baker's
yeast to
identify genes crucial in autophagy, the process by which cells recycle their components.
Here the homologous
genes from the fission
yeast Schizosaccharomyces pombe and human are
identified.
They
identified and isolated a
gene family with GNA1 function, which was confirmed by enzyme activity assays in vitro and by its capacity to restore growth in
yeasts lacking GNA1.
He
identified some
genes in the pathway and studied how it was regulated, comparing it to bacteria and
yeast.
After
identifying that short strand of DNA, the team members inserted it into
yeast DNA and were able to grow copies of the few dozen
genes it contained.
They then
identified a novel enzyme at work in A. annua that completes the artemisinic acid synthesis and popped the
gene for the enzyme into their
yeast.
A dual
yeast and human stem cell discovery platform for Parkinson's disease: Investigations in simple baker's
yeast cells brought to light abnormalities in Parkinson's patient neurons and
identified genes and small molecules that correct them.
Next, like every good
yeast researcher should, they turned to the Saccharomyces Genome Database (SGD) to
identify 86
genes that when knocked out, caused the mutant
yeast strain to not grow in the absence of an amino acid.
Their contributions to the
yeast community include physical mapping methods, synthetic lethality screen approaches for
identifying cross-species candidate
genes as potential cancer drug targets, and a widely used set of vectors and
yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.
October 5, 2015 / Novato, California Following an exhaustive, ten - year effort, scientists at the Buck Institute for Research on Aging and the University of Washington have
identified 238
genes that, when removed, increase the replicative lifespan of S. cerevisiae
yeast cells.
Identify genes and
gene products involved in trafficking of proteins to the lysosome of Baker's
yeast; study their conservation in humans and their connection to human diseases such as Alzheimer's and cancer.
The research team
identified predictive models of transcription — the first step in
gene expression — when the
yeast cell is responding to osmotic stress (salt), which greatly affects cell growth.
Breeden, Prentice and Zhao, whose study appeared in the May 8 Proceedings of the National Academy of Sciences, compared their new algorithm to other methods used to analyze microarray experiments designed to
identify cell cycle
genes in
yeast.