Sentences with phrase «identifying cell fate»

Not exact matches

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage fates.

Researchers have identified a set of DNA - binding proteins in the roots of the plant Arabidopsis thaliana that work in combination to help precursor cells selectively read different parts of the same genetic script and acquire their different fates.

«This finding not only identifies a new mechanism that regulates totipotent stem cells, but also reveals the importance of non-coding RNAs in stem cell fate.»

The expression of specific genes in a particular root cell determine its fate — the zone in which it will function, Subramanian explained, so he is identifying which micro-RNAs direct gene expression to achieve this differentiation.

With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?

Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.

Genetic approaches in mouse model systems combined with cell biological assays have allowed Professor Lukas Sommer to identify mechanisms regulating stem cell fates in the developing CNS and in neural crest - derived tissues.

His group defined a functional niche for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.

Next, we identified genes whose expression was associated with Th1 or Tfh fates, and demonstrated a T - cell intrinsic role for Galectin - 1 in supporting a Th1 differentiation.