Sentences with phrase «identifying damaged genes»

VAAST (the Variant Annotation, Analysis & Search Tool) is a probabilistic search tool for identifying damaged genes and their disease - causing variants in personal genome sequences.

Not exact matches

Eventually, scientists might even be able to learn how to re-modify damaged genes to reduce the risk for diseases, and the finding could help researchers identify chemical compounds and foods that fight disease by repairing those genes.

The newly identified gene affects accumulation of amyloid - beta, a protein believed to be one of the main causes of the damage that underpins this brain disease in humans.

In a previous study, his team worked with other collaborators to identify the potential role of extra copies of the tumor suppressor gene (p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.

A comprehensive DNA sequencing of pancreatic cancer cases revealed not only a plethora of damaged genes, but potential diagnostic biomarkers that could help identify those with longer or shorter survival, and provide opportunity for new therapeutic interventions.

«By identifying the full set of genes in each of these two cell types, we provide detailed information that taste scientists can use to help understand how these cells work, both when healthy and also when affected by damage or disease.»

Previous work by Freeman's lab identified another enzyme, a gene called SARM, which was the first shown to activate a process that causes axons to disintegrate when damaged.

Azot: The azot gene in fruit flies is a part of a mechanism by which cells collaborate to identify damaged or dysfunctional neighbors, flagging them for destruction and replacement.

Researchers have identified a protein that activates the well - known tumor suppressor gene p53 to prevent the division of cells that have damaged DNA.

They then identified damaging mutations in the children that would disable the protein produced by a particular gene or alter the protein's function.

Our work identified that these sarcomas lack most of the normal damage responses because of an RNA metabolism issue that traps the BRCA1 protein, the gene usually associated with breast cancer.

By performing a meta - analysis of rare coding variants in whole - exome sequences from 4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes previously identified as having a near - complete depletion of loss - of - function variants.

Haldar identified a drug that inhibits these proteins and returns their activity levels to normal, blocking the harmful changes in cardiac gene expression and halting the progression of heart damage.

We identified 94 genes enriched in damaging DNMs, including 14 that previously lacked compelling evidence of involvement in developmental disorders.

Howard Hughes Medical Institute (HHMI) researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage.

The metabolic theory of cancer (Warburg, Seyfried) looks much more promising, and under it, cancer is triggered by the familiar numerous identified carcinogens, which cause mitochondrial damage (not gene damge), but is fed by glucose, and is arrested or killed by ketone bodies (ketogenic diet).

«The risk factor we have identified is in a gene known to repair UV - caused damage to DNA,» said Dr. Bellone.