Using genetic modification in this way can improve the accuracy of
identifying genes of interest and speed up the breeding process, even though the end - product is not GM rice.
These findings are a proof of concept of novel methods to functionally annotate genomes in order to more quickly
identify genes of interest.
Not exact matches
To gain more insights as to why zebrafish are more successful at regenerating spinal tissue, the researchers analyzed the
gene expression
of fish spinal tissue following injury,
identifying seven
genes of interest.
Genomics - based discovery is key for
identifying genes of potential
interest to plant breeders and biotech seed developers.
«Our team studied thousands
of molecular clues in each
of these samples, sifting through extensive data on the activity
of genes, proteins and other molecules to
identify those
of most
interest,» says Katrina Waters, a biologist at PNNL and a corresponding author
of the study.
«Our team studied thousands
of molecular clues in each
of these samples, sifting through extensive data on the activity
of genes, proteins, and other molecules to
identify those
of most
interest,» said Katrina Waters, the leader
of the PNNL team and a corresponding author
of the paper.
This under - expression was particularly
interesting because although hundreds
of genes have already been
identified for their presumed roles in autistic disorders, each one alone can at best only explain 1 %
of cases.
A year ago we started thinking, why don't we select a single family with an
interesting disease and see whether studying a smaller group
of related individuals makes it possible to
identify the
genes involved in that disease.
The Finnish researchers had used a set
of «
gene wrenches» called RNAi molecules, to turn off
genes of interest, and with these additional experiments the researchers
identified tracks leading to a nuclear protein and
gene controller protein called SRF.
A second project, dubbed Eumorphia, will organize more than a dozen labs in nine countries to systematically screen new mouse mutants for
interesting characteristics — a key step in determining the function
of newly
identified genes.
Thus µSCALE empties the contents
of a single capillary onto a collector plate, where the DNA
of the isolated cell can be sequenced and the
gene variant responsible for the protein
of interest can be
identified.
«We have deposited all the data and the toolkit in a public platform, which will help researchers
identify and validate the functions
of their
genes of interest,» says Auwerx, placing the project within the context
of EPFL's ongoing efforts to advance open science.
A well - defined cell type that has been widely used to
identify the consequences
of ablation or ectopic expression
of a
gene of interest.
The United Kingdom - based group, led by Julie Williams, Ph.D., Cardiff University School
of Medicine, Wales, found the same
genes as risk factors and
identified a
gene variant ABCA7 as an additional
gene of interest.
Botstein and Davis» landmark conceptual breakthrough, published in 1980, gave researchers the tools to trace and map out the genetic inheritance
of disease in humans, while Hogness» work provided the means
of identifying the precise physical location
of genes of interest on chromosomes.
By comparing the whole genome sequence
of the lab - cultured resistant strain with a sibling strain that had not been exposed to the drug, they were able to
identify several mutations
of interest in a number
of genes.
He is also
interested in
genes induced by the interferon response, and his future plans include investigating
genes identified in the expression
of genome - wide association screens for predisposition to cancers.
Restricting these differentially expressed
genes to ones that changed by at least 4-fold in any comparison, at a stringent p - value cutoff
of P < 0.0001, we
identified three groups
of biologically
interesting genes.
His research team is
interested in
identifying genes that direct the development
of the cerebral cortex, both because
of their importance in human diseases and because studying those
genes will help in learning about the normal development and evolution
of the brain.
The Bioinformatics group uses computational methods to analyse genome sequences, amino acid sequences, and
gene expression data, both to
identify new
genes of interest and to determine their structure, function and role in the cell.
However, if the purpose
of such a scan is to
identify candidate
genes, then — as with single -
gene studies — more detailed follow - up and functional validation
of at least some
of the key
genes of interest are necessary to shore up the evidence.
Homozygosity mapping
of 5 cases (4 full - sibs, 1 half - sib) and 5 controls (2 parents, 3 full - sibs) via Illumina CanineHD SNP genotyping BeadChips
identified a single chromosome (canine chromosome 36; CFA36)
of interest where the
gene containing a responsible mutation is expected to be located.
Genetic testing — which the report describes as «the analysis
of a person's chromosomes,
genes, or
gene products (proteins) to
identify the presence
of specific traits» — is accessible to Canadians
interested in learning more about their predisposition to certain health issues, or for diagnosis.