Sentences with phrase «identifying host genes»

Early adaptations of the initial technology were used in functional genomics screens identifying host genes affecting HIV [2] and Trypanosome infection.

Not exact matches

Here's how it works: Scientists identify the desired genes in a plant or animal and insert them into a host such as yeast.

«We have identified the molecular mechanisms by which the Tat protein made by HIV interacts with the host cell to activate or repress several hundred human genes,» said Dr. Iván D'Orso, Assistant Professor of Microbiology at UT Southwestern and senior author of the study.

Studies seeking subtle signs of selection in the DNA of humans and other primates have identified dozens of genes, in particular those involved in host - pathogen interactions, reproduction, sensory systems such as olfaction and taste, and more.

To learn how Mycobacterium tuberculosis mounts a defense against a drug, Baliga is first looking within the bacterium, identifying the genes, proteins and other molecules that interact as the microbe infects a host.

Though viruses are generally thought to take over whatever organism they invade, Sullivan's lab has identified a few viruses, called prophages, which coexist with their host microbes and even produce genes that help the host cells compete and survive.

Researchers have identified a new host of gene variants that could make people vulnerable to sporadic motor neuron disease, according to a report published in the journal, Scientific Reports.

They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian - defensin gene families.

Further genetic studies should enable researchers to identify other genes that have been dropped or acquired through evolution, giving microorganisms the characteristics they need to colonize their hosts and cause disease.

For example, when the researchers decoded the complete sequence of one extrachromosomal circular phage from a disease - causing Staphylococcus, they identified a number of genes that may help this strain evade a host's immune system and that could readily spread to other Staphylococcus bacteria.

Both groups are analyzing the sequence to identify genes that will reveal how the pathogen causes disease and interacts with the plant host.

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.

He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.

Since its genome was sequenced in 2002, scientists have identified a number of genes involved in how the parasite functions inside its host to cause malaria.

Therefore, these reference genomes can also enable further studies, such as identifying gene expression changes that explain multidrug resistance and host interaction.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.

We identify 23 genes that, when disrupted in mouse, modify the ability of tumour cells to establish metastatic foci, with 19 of these genes not previously demonstrated to play a role in host control of metastasis.