By
identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.»
«This is a seminal step in
identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»
Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to
identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.
Not exact matches
The introduction of the GCSE is also
identified as a
key educational reform, opening
pathways for the majority.
Key brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effe
Key brain regions have been
identified by imaging studies, as have
key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effe
key neurochemical
pathways bringing about the possibility of using drugs to block the nocebo effect.
Two new members of a
key pathway responsible for pattern formation during vertebrate development have been
identified.
Looking to target a
key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has
identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.
«We
identified the cytosolic protein Vms1 as a
key component of a novel
pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.
The scientists
identified several, including the investigational cancer drug BEZ235, which blocked a
key metabolic
pathway in flu - infected human lung epithelial cells.
She says mutations in
key players of the mTOR
pathway, a molecular
pathway present and active in several types of cancer, have been
identified in pNETs.
One of the most robust alterations was observed in the JAK - STAT3
pathway and the production of serum amyloid A (SAA)-- a protein which has only recently been
identified as a
key player in the body's immune response.
Kanneganti emphasized that their discoveries have fundamental importance, because they
identify a
key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death
pathways.
When the researchers used optogenetics, a biological technique which involves the use of light to control neurons, to inhibit the
key social - spatial
pathway they had
identified in the brain, the test mouse wandered freely through the space.
EDMONTON, ALBERTA — Researchers have
identified a
key cellular
pathway by which the herbal medicine ginkgo biloba may protect brain cells.
Now a team has elucidated the biochemical
pathway responsible, as well as
identified the
key enzymes involved.
«Nutrient sensor in
key growth - regulating metabolic
pathway identified.»
«The bioinformatics tools have matured to the point that we can now find the proverbial «needle in a haystack,» meaning we can now
identify genes and
pathways that are unique to pathogenic microbes, which will focus future research efforts on these
key pathogen - specific features,» Fouts said.
With collaborators in the biology department, Dr. Weiss applied these ultrasensitive techniques to investigate the Hedgehog signaling
pathway — a critical mechanism that helps give rise to the spatial patterning in developing embryos, but has also been
identified as a
key culprit in up to 25 % of cancer deaths.
A
key next step in the ALS investigation will be to
identify the
pathways that lead to loss of the inhibitory neurons and the behavioral defects.
Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of
identifying the underlying disease
pathway and
key drug targets.
The aim of this study is to
identify potential
key genes and
pathways that are related to the calcification apparatus.
«What is more, the technique
identifies key genes and enriched gene ontology
pathways, as well as categories related to stem cell differentiation — and specifically toward osteochondral lineages (that is, related to bone and cartilage tissue growth).»
The Gladstone team had profiled changes in gene expression using DNA microarrays, which provides an unbiased method for
identifying key biological
pathways.
We
identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a
key regulator of the Rab3
pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.
The
key biological
pathways that are
identified will then be targeted therapeutically through rational clinical trial strategies.
We are currently
identifying the downstream effectors of this CAMKK2 - AMPK kinase
pathway including Tau and some
key effectors of autophagy.
This is why recent work in the field of cancer research has focused on picking apart the complex cellular
pathways involved in the development of different cancers and
identifying the roles of
key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.
Neuroinflammation and ferroptosis were
identified as
key molecular
pathways underlying iron toxicity.
We have
identified the coral homologs of many of the
key molecules that are involved in apoptotic and cell death
pathways in higher organisms.
Scientists in the lab of Whitehead Institute Member David Sabatini have for the first time
identified a protein that appears to be a nutrient sensor for the
key growth - regulating mTORC1 metabolic
pathway.
Using a new in vivo screening system, Whitehead Institute researchers have
identified a protein in a
key metabolic
pathway that is essential in estrogen receptor (ER)- negative breast cancer.
Identifying any Hymenoptera - specific immune
pathways or effectors that may exist is also of
key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].
To
identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent
pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.
University of California San Diego (UCSD) School of Medicine researchers have
identified an enzyme that plays a
key role in controlling these metabolic changes, suggesting we could tweak this
pathway artificially to help our bodies burn fat more efficiently.
By assessing the incidence of a particular mutation or the frequency at which certain genes /
pathways are altered across multiple patients (of the same tumor type), it should be possible to
identify key mutations.
By comparing
key biochemical reactions in the cells of fasted and fed scid and B6 mice, the research team was able to
identify and describe the highlighted steps (formerly missing links) in the following feeding - induced insulin signaling
pathway.
The Diplomás team has
identified four
key policy areas to target as they work towards the attainment goal: counseling and advising, dual credit, student support
pathways, and college affordability.13 P16Plus supports these policy areas using data to help inform those efforts that are most successful for students.
Many residents
identify this strong financial support as a
key reason why they chose SFTR over other
pathways into teaching.
Through the development of the Organizer, we have
identified key considerations for policymakers, practitioners, and the public as they reflect on the
Pathways and Supports strand within their local contexts.
Key sectors of the economy
identified for building career
pathways include STEM fields such as information technology, health care, and advanced manufacturing.
• Provide a clear, evidence - based explanation of the role played by different parts of the energy sector in causing air pollution • Present detailed projections of the energy sector and related air quality
pathways in different countries and sectors, based on known energy, climate and air quality policies, and the
key implications for policymakers •
Identify additional policy measures that can materially improve the outlook for energy - related air pollution, examining both the co-benefits and trade - offs with other energy and climate objectives • Based on analysis of different policy options, distil the
key findings of the report into a clear set of implications and recommendations for policymakers
The U.S. Department of Health and Human Services
identified career
pathways as a
key strategy to help states and programs address inconsistent compensation, expectations, and professional development across sectors.54 Career
pathways identify a sequence of credentials that are reflective of progressively higher competencies and are tied to particular roles or job titles.
Strategies: Increase number of Aboriginal teachers; develop
pathways in education, training and employment;
identify key strategies and negotiate with DEST and other stakeholders.
assisting agencies to address
key barriers to the employment of Aboriginal and Torres Strait Islander employees, by
identifying pathways to employment that allow Indigenous people to develop the required skills and capacity to work within the APS;