Sentences with phrase «identifying key proteins»

The effort to identify new ways of fighting infections has taken a step forward now that scientists have identified a key protein involved in the host's response to strep infections.

This approach helped him identify a key protein that helps plants avoid photooxidative damage in high - light conditions.

The study, «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» was supported by the National Institutes of Health.

N. Yasui et al., «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» Molecular Cell, doi: 10.1016 / j.molcel.2014.05.002, 2014.

«It will be important to identify the key proteins and metabolites that are dynamically secreted by muscle during exercise to meet the brain's physiological demands,» they write.

Although researchers had identified the key proteins involved, that is, middle T antigen for polyomavirus and Src for Rous, they weren't sure what those proteins did.

In prior work, his lab has identified a key protein in the model plant Arabadopsis.

The researchers also identify a key protein that, if blocked, could create the effects of a keto diet.

Not exact matches

Jadwiga Giebultowicz of Oregon State University has identified PER and TIM proteins — key components of biological clocks — in the kidney like malpighian tubules of fruit flies.

Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.

«We identified the cytosolic protein Vms1 as a key component of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.

«Regulator of chromosome structure crucial to healthy brain function and nerve development: Cohesin protein identified as key to control of chromosome structure underlying nerve cell network formation.»

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

«Scientists identify proteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells growproteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells growProteins play key role in genes that help auditory hair cells grow.»

Mayo Clinic researchers have identified that a key drug target, CDK4 / 6, regulates a cancer metastasis protein, SNAIL, and drugs that inhibit CDK 4/6 could prevent the spread of triple - negative breast cancer.

«Protein key to cancer cells ability to spread identified.»

The team has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases.

A team of scientists has now identified proteins, which play a key role in the production of rubber in the plant.

Dr. Espen Spangenburg, associate professor of kinesiology, and his laboratory team are the first to identify that the BRCA1 protein is expressed in the skeletal muscle of both mice and humans, and that it plays a key role in fat storage, insulin response and mitochondrial function in skeletal muscle cells.

One of the most robust alterations was observed in the JAK - STAT3 pathway and the production of serum amyloid A (SAA)-- a protein which has only recently been identified as a key player in the body's immune response.

Research carried out by the University of Sussex and the Polish Academy of Sciences has identified two key proteins that allow mycobacterium tuberculosis, the causative agent of tuberculosis (TB), to «lay low» within cells designed to destroy them.

In the latest study, published in Nature Microbiology, the team have identified two key proteins that malaria parasites need to escape red blood cells and infect fresh cells.

Researchers from RIKEN in Japan have identified a duo of histone proteins that dramatically enhance the generation of induced pluripotent stem cells (iPS cells) and may be the key to generating induced totipotent stem cells.

Bettencourt Dias» team tackled this question by focusing on the key molecular trigger of centriole formation, a protein called PLK4, which they identified recently.

Here we identify protein kinase N1 (PKN1) as a novel key...

In 1988, Scheller identified the first key vesicle membrane protein, which he termed VAMP, now also known as synaptobrevin.

Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).

We identified Protein Kinase C - theta as the first key protein that serves as master switch for determining the physiological outcome to initial T cell actiProtein Kinase C - theta as the first key protein that serves as master switch for determining the physiological outcome to initial T cell actiprotein that serves as master switch for determining the physiological outcome to initial T cell activation.

Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of identifying the underlying disease pathway and key drug targets.

Klemke's laboratory has already identified several candidate proteins using this technique that may be key players in pseudopod formation and cell movement.

Using biochemical methods and mutational analysis, they were able to identify key parts of the protein that are required for slicing activity.

We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.

Known key pathological mechanisms are related to defects in structural proteins, nuclear proteins, intermediate filaments and other cyoskeletal proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.

Richard Scheller has used a combination of biochemistry, molecular biology, and cell biology to identify several key synaptic vesicle and plasma membrane proteins involved in fusion of the neurotransmitter - containing vesicles with the membrane of the presynaptic terminal.

This is why recent work in the field of cancer research has focused on picking apart the complex cellular pathways involved in the development of different cancers and identifying the roles of key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.

Scientists in the lab of Whitehead Institute Member David Sabatini have for the first time identified a protein that appears to be a nutrient sensor for the key growth - regulating mTORC1 metabolic pathway.

Using a branch of mathematics called information theory, Califano's team, along with Mariano Alvarez, PhD — DarwinHealth's Chief Scientific Officer — developed algorithms that can identify these critical proteins — dubbed «master regulators» — that hold the key to the malignant behavior of cancer cells.

«We identified additional key components to PSII involved in assembly and function,» said Dr. Jon Jacobs, a protein chemist at PNNL.

Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)- negative breast cancer.

Scientists are claiming to have zeroed in on the culprit that makes losing weight difficult for obese people, identifying a protein that stops fat cells from burning energy which they say could become a key target in treating obesity and other metabolic conditions.

«Importantly, this analysis helped us identify the protein fibrinogen as the key culprit in MS, by demonstrating how its entry into the brain through leaky blood vessels impacted the health of individual nerve cells.»

Whitehead Institute scientists have identified a protein whose inhibition could hold the key to alleviating suffering caused by such disorders.

With the discovery of Asgard» clade archaea, the homologs of key eukaryote cytoskeletal proteins have, for the first time, been identified in archaea.

CAMBRIDGE, Mass. (Sept. 23, 1999)-- Scientists at the Whitehead Institute for Biomedical Research and Millennium Pharmaceuticals, Inc. have identified a protein in the small intestine that plays a key role in the uptake of dietary fat into the body.

We and others have identified NMNAT2 (nicotinamide mononucleotide adenylyl transferase 2) as a neuroprotective protein key to maintaining neuronal integrity throughout life.

Subsequent work identified a different protein on the surface of T cells — PD - 1 — as another key regulator of T cell response.

Researchers at Whitehead Institute have identified a key target protein of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy.

New research identifies three key lifestyle factors that seem to be linked with reduced protein buildups associated with Alzheimer's.

A protein that appears to play a key role in the formation of lymphoma and other tumors by inhibiting a tumor - suppressing gene has been identified by a team of veterinary and human medicine researchers at the University of California, Davis.