Sentences with phrase «identifying novel therapies»
Coupled with a review of these results by experts on a molecular tumor board, the opportunity exists to identify novel therapies that would target specific abnormalities,» notes senior author of the work, Shridar Ganesan, MD, PhD, associate director for translational science at Rutgers Cancer Institute and associate professor of medicine and pharmacology at Rutgers Robert Wood Johnson Medical School.
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«Researchers identify novel mechanism in combination drug therapy for acute myeloid leukemia, other cancers.»
He hopes that further studies may identify novel approaches to immune - based cancer therapy or reveal new drug targets for inflammatory diseases.
This is important because it makes it possible to model almost any autoimmune disease, evaluate new drug therapies, and even identify novel targets in the emerging area of cancer immunotherapies.
The study authors write that using the LSC17 score to single out high - risk patients predicted to have resistant disease «provides clinicians with a rapid and powerful tool to identify AML patients who are less likely to be cured by standard therapy and who could be enrolled in trials evaluating novel upfront or post-remission strategies.»
One GSC subtype called the mesenchymal GSC is more malignant and the most therapy - resistant, so Nakano and fellow researchers reasoned that identifying the regulatory molecules active in mesenchymal GSCs might lead to novel and effective therapeutics.
Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified novel genomic and molecular characteristics of cervical cancer that will aid in the subclassification of the disease and may help target therapies that are most appropriate for each patient.
«At Exeter we are already developing specific psychological therapies, running clinical trials of novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective therapies and to allow us to use current treatments in a more focussed way.»
«There are currently no drug therapies available that improve the very limited natural recovery from spinal cord injuries that patients experience,» said Lyn Jakeman, Ph.D., a program director at the NIH's National Institute of Neurological Disorders and Stroke, Bethesda, MD. «This is a great step towards identifying a novel agent for helping people recover.»
Discovery of a novel, advanced technique to identify the rare cells where human immunodeficiency virus (HIV) hides in patients taking antiretroviral therapy (ART).
«We've identified what leads to this difference in vision loss, and that suggests novel potential therapies to treat this serious medical problem in children.
«We are currently identifying the genes responsible for generating the DNA tether, which could be promising novel targets for the next generation of cancer therapies.»
Other areas of research include designing novel therapies based on molecular pathways and identifying predictive biomarkers in patients to design personalized, targeted therapies.
Researchers have identified a novel mechanism by which cells die in Alzheimer's disease, which my aid future therapies targeting cell loss in the brain.
We now currently have enough information about genetic factors that contribute to glaucoma that we really can begin to identify biological processes and proteins that contribute to the disease, making it possible to develop novel therapies that actually target those processes and proteins.
My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.
At present, there is an urgent clinical need to extend our understanding of PD pathology, to develop novel disease - modifying therapies for PD, and to identify reliable PD biomarkers to allow for earlier interventions.
A major goal is to integrate genetic, clinical, and laboratory features to identify patients who share disease biology and clinical outcome, such that therapies, both existing and novel, can be better targeted.
My research efforts are focused on identifying novel combination therapies for breast cancer and the mechanisms that lead to drug resistance.
Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.
By identifying novel molecular targets and potential new drugs, this powerful technological structure will contribute significantly to groundbreaking research towards the development of new anti-cancer therapies.
His research focuses on developing new therapies and identifying novel prognostic and predictive biomarkers for canine lymphomas.
We also postulate that Treg frequency and Treg: CD8 + ratios will act as prognostic indicators of survival and may help identify novel targets for anti-cancer therapy.
* Expertise in developing novel combination therapies, identifying drug resistance mechanisms, signaling pathways, tumor microenvironment.
Informed by the literature on risk factors for IPV maintenance, drawing from the broader psychopathology and psychotherapy literatures, and guided by third wave behavior therapy models, Dr. Lawrence and her students developed a new conceptual model identifying novel processes that underlie the propensity for violent perpetrators to continue engaging in IPV, applied that model to a novel intervention, and then tested the efficacy and effectiveness of that new intervention.