When you are looking for potential SNPs, particularly without a reference genome, you run the risk of
identifying sequence differences between duplicated sequences rather than differences between individuals.
Not exact matches
Now begins the methodical job of homing in on the promising parts of the
sequence and
identifying the
differences that count.
Collins already had developed a method to
identify ancient species by
differences in the amino acid
sequences of collagen and other proteins preserved in fossils.
Then they checked blood samples against half a million known variations in DNA
sequences, or single - nucleotide polymorphisms, which recently were
identified by the International HapMap Project that looked for
differences in the genomes of people from many populations.
Find out how forensic detectives tease out slight
differences in DNA
sequence to
identify individuals.
By
sequencing multiple butterfly genomes and
identifying patterns of genetic divergence in areas critical to biotic interaction, such as wing pattern and host - plant usage, he and his team hope to
identify differences that reveal the causes of accelerated speciation and greater biodiversity in the tropics.
In the
sequencing of five candidate genes (LPL, LCAT, ABCA1, PON1, and SERPINE1), rare and common SNPs were
identified that were associated with
differences in serum lipids.
Sequence polymorphisms in this gene between susceptible and resistant strains were
identified that may account for the
difference in phenotype.
Recently, a new chicken reference genome assembly Gallus Gallus v5 was generated using Sanger, 454, Illumina and PacBio
sequencing technologies
identifying considerable
differences in the chIFITM locus over the previous genome releases.