The two most common causes of adult - onset primary hypothyroidism in dogs include lymphocytic thyroiditis and
idiopathic atrophy of the thyroid gland.
Idiopathic atrophy of the thyroid gland is characterized histologically by loss of thyroid parenchyma and replacement by adipose tissue.
In the case of
idiopathic atrophy, when the body is fighting a toxin, foreign body, virus or bacteria, the body's response (called a cell medicated immunity or lymphatic response) also reduces the the activity of growth hormones such as those released by the thyroid.
Thyroiditis (Inflammation of thyroid gland) &
idiopathic atrophy (no growth in gland due to a pathogen of the thyroid gland are two main reasons for impairment in the thyroid gland function or secretions.
Not exact matches
If so, it's caused by lymphocytic thyroiditis or
idiopathic thyroid
atrophy:
Causes include pancreatitis or
idiopathic pancreatic acinar
atrophy, where the production of enzymes responsible for fat, protein and starch digestion is reduced.
Idiopathic thyroid gland
atrophy is also poorly understood.
In the dog, hypothyroidism is usually caused by one of two diseases: lymphocytic thyroiditis or
idiopathic thyroid gland
atrophy.
In the other half of primary hypothyroid cases, a specific cause of thyroid gland damage can not be found; these cases are known as
idiopathic follicular
atrophy in which the hormone - producing cells (follicles) of the thyroid gland waste away (or
atrophy) for an unknown (i.e.
idiopathic) reason.
In other cases, there is a loss of functional thyroid tissue for unknown reasons, a condition known as
idiopathic thyroid
atrophy (Gosselin et al., 1981).
Less frequently encountered diseases include, Addison's Disease, autoimmune testicular
atrophy, degenerative myelopathy, dermatomyositis, exocrine pancreatic insufficiency, glomerulonephritis,
idiopathic thrombocytopenic purpura, immune mediated hemolytic anemia, Legg - Calvé - Perthes, myasthenia gravis, sterile pyogranuloma / granuloma syndrome, uveodermatologic syndrome, and vitiligo.
Work currently being undertaken involves
idiopathic epilepsy in Border Collies and hereditary cataract and progressive retinal
atrophy in many breeds, including Siberian Huskies, Miniature Schnauzers and Tibetan Spaniels.