Sentences with phrase «if gene copy»

In this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA «fingerprints» of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatment.

Not exact matches

Things get more complicated if the gene is recessive and a woman would need to get copies of the gene from both parents in order to express it.

If you're a carrier of a defective gene for a recessive disorder, that means you have one normal copy of the gene from one of your parents and one defective copy from the other.

If you have one non-functional copy of the gene, you're fine.

Because there's only one functioning allele of an imprinted gene, if that copy becomes defective, developmental abnormalities can occur.

So Sandra Ryeom at the Children's Hospital in Boston and colleagues bred mice with three genes to find out if an extra copy gave them extra protection against cancer.

If you inherit one copy of a particular gene mutation it seems to protect you from Alzheimer's.

But if the father's copy is missing, the cells can't express that gene at all.

The discovery could mean that it will be difficult for researchers to fix mutations in embryos if neither parent has a healthy copy of the gene.

If the other gene were located on the part of the circle that was copied last, the ratio of KinA to Spo0F would be one - to - one only when DNA replication was nearly completed.

«Fetal sex determination allows targeting of invasive testing to see if the female fetus is carrying two mutant copies of the CAH gene and is therefore affected.

Those results are the same if the enhancers are intact but both copies of the gene itself are defective, indicating that the amount of protein determines the number of digits.

However, if a corrected copy of the gene is also delivered when the cut is made, the DNA repair can lead to correction of the disease gene, permanently repairing the genome.

«But, in any event, if the protein translated from the remaining good copy of the gene is then targeted by SNO, then you are stuck making dysfunctional PINK1 even from the remaining good copy of the gene,» said Lipton.

Because humans inherit two copies (one from each parent) of the gene that encodes PINK1, we all have at least one copy of the gene if the other is mutated.

If a copy number variation disrupts certain genes, it is more likely to lead to autism.

If one copy of the SLC2A1 gene is completely dysfunctional, the results are devastating: The brain develops to only a portion of its normal size.

If neither copy of the gene works, a fetus simply dies.

If the gene encoding a protein is duplicated in the genome, which often happens in evolution, original and copy will interact with the same partners in the protein network.

If a mutated gene causes damage to or spurs the disappearance of a necessary protein, for example, gene therapy may be able to introduce a normal copy of the gene to restore the function of that protein.

Rather gene dosage, which depends on the number of chromosome copies, is responsible for this: «If the chromosome is multiplied, then more copies of the same gene will be transcribed.

As reported in the new study, the researchers were able to postpone the onset of hearing loss and associated hair cell degeneration by about a month, providing enough time to inject normal copies of the Clarin - 1 gene into the ear before the onset of hearing loss to see if the treatment was effective.

(My admittedly wild hypothesis is that the gene, CD32, may help drive Zika virus to copy itself to higher levels if a person was previously infected with dengue and has antibodies to that virus.)

If both copies of the gene are deleted from developing mouse fetuses, they terminate before birth due to arterial rupture and hemorrhaging.

According to Dr. Wong, «This combined strategy provides us with a new tool for reliable molecular analysis of any genes containing multiple copies of highly homologous sequences and should improve the positive finding rate for patients with Lynch syndrome if the PMS2 gene is suspected to be defective.

One common indicator of high - risk cancer is if a child has extra copies (amplification) of a gene called MYCN (pronounced mick - N).

If the function of these genes can eventually be worked out, treatments might be found to improve the mental capacity of patients carrying damaged copies.

Undamaged copies of these genes are probably essential if people are to develop an IQ within the usual range.

That way, even if the original genes in the mitochondrial are deleted, the backup copies will be able to supply the proteins needed to keep normal energy production going, allowing the cellular power plants to continue humming along normally and preventing them from entering into the toxic, mutant metabolic state.

«If a patient has a mutation in a specific gene, it would be a way of giving them a normal copy to try to correct that gene.

In multicellular organisms, functional duplicate copies of a gene can exist in a genome, but if their expression patterns do not overlap, their products are unable to compensate for each other if either gene is mutated.

DNA is precious - if we screw up our DNA we end up with cancer, or dead - so the cellular managers of the DNA make a copy of the requested gene.

If one copy of one of these genes from one parent is already mutated at birth, the second normal copy from the other parent often can compensate for the defect.

Bacteria tend to maintain fewer copies of plasmids if they contain large inserts or genes that create a toxic product.

If one of these genes is not working, there is not another copy to compensate.

He mentioned that tumor cells will perish if they lose all six copies of their HLA genes.

The result: an embryo with two healthy copies of the gene that, if implanted in a woman and allowed to gestate, should result in a baby free from risk of hereditary cardiomyopathy.

If you have zero copies of the ApoE4 gene your lifelong chance of developing Alzheimer's is about nine percent.

Additionally if our patients are positive for any copy of the gene, heavy metal testing should be done.

If you have two copies of this gene variant, you metabolize caffeine much slower than «fast» caffeine metabolizers.

Some people currently recommend that if the cat has two copies of the gene, the cat should not be used for breeding.

But if the cat has one copy of the gene, he should also be screened periodically for the disease, although his status for breeding is much better.

DNA test results will indicate if the cat has the mutation on 1 copy of its 2 gene copies (called heterozygous) or both gene copies (homozygous).

If a working copy of the gene is present in a domestic cat, it will result in the narrow striped mackerel pattern; if the gene is turned off by a mutation, the cat will display the traditional blotchy or marbled tabby patterIf a working copy of the gene is present in a domestic cat, it will result in the narrow striped mackerel pattern; if the gene is turned off by a mutation, the cat will display the traditional blotchy or marbled tabby patterif the gene is turned off by a mutation, the cat will display the traditional blotchy or marbled tabby pattern.

It's important to note that the test only indicates if the dog has one, two, or no copies of the gene associated with DM.

In several breeds, particularly Samoyeds and Siberian huskies, PRA is passed on in a dominant inheritance pattern, meaning that even if a dog gets only one copy of the gene, it will develop the disease.

If the offspring get two copies of the gene, they will be born too small to live longer than a few days.

Certainly, if the currently offered stud dog is used, it will introduce the recessive b gene rapidly into our dogs as every offspring will carry at least oen copy of the recessive b gene an serve as carriers.

The other (still unidentified) genes only contribute to the trait if two copies of the CEA - CH mutation are present.

In other words, if the dog is only carrier, i.e he has only one defective copy of a gene, he will be clinically healthy.