«It is really remarkable that even
if the undamaged and the damaged
guanine are bound in the active centre and assume identical positions, only the oxidized form of
guanine is excised from DNA by the human repair enzyme hOGG1,» says Sadeghian, first author of the study.
If an unzipped segment of DNA is added as a template to a solution with the tPNA components, the nucelobase soldiers will automatically assume a formation on peptide strands that complements the DNA according to standard Watson - Crick pairing of adenine with thymine and cytosine with
guanine.