Sentences with phrase «imaging agent»

I also provide advice on regulatory requirements and necessary steps associated with advancing drugs, devices and imaging agents toward clinical trials in patients.

She also conducts clinical research evaluating prognosticators of outcome in patients with liver, bile duct and liver tumors and investigates new imaging agents in pancreas and liver cancers.

With new imaging agents available for both of these proteins, we will be able to quickly reach proof - of - activity of GAIM's mechanism, which will provide us with a gateway into additional indications,» commented Franz Hefti, President and Chief Operating Officer.

Nanoparticles for the sole use of imaging agents have a much lower return on investment and higher safety requirements than drug delivery systems... -LSB-...]

Test that uses imaging agent to detect protein buildup may get government funding, but only in limited cases

Our Mission is to advance the use of molecular imaging agents in clinical trials through standardization of chemistry and imaging methodology.

But in the past several years, researchers have developed PET imaging agents that can harmlessly bind to tau in the living brain.

Studying heparanase — a key enzyme in the development and metastasis of human cancers — scientists unveiled new fluorescent imaging agents that detect enzyme activity in healthy and diseased tissues.

Dr. Sanford, who is both a member of the National Academy of Sciences and recipient of a MacArthur «genius grant,» has designed molecules that can be used to store energy in batteries, serve as new medical imaging agents, convert carbon dioxide into fuels, or serve as pharmaceuticals to treat disease.

For this study, 10 subjects with Alzheimer's underwent PET following the injection of three radiotracers: fluorine - 18 fluorodeoxyglucose (F - 18 FDG), which images regional metabolic activity; carbon - 11 Pittsburgh compound B (C - 11 PiB), which has an affinity for amyloid plaques; and F - 18 AV - 1451, an emerging imaging agent that binds to tau in the brain.

Stanford University medical scientists have developed a novel imaging agent that... Read more

18F - AV - 1451 is a brain imaging agent used in PET (Positron Emission Tomography) Scans.

Research presented at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) shows how a new molecular imaging agent finds prostate cancer that has spread to other tissues by locking in on an enzyme called prostate specific membrane antigen (PSMA), associated with prostate cancer.

Direct positron imaging is a nuclear medicine technique that allows researchers to gain physiological information from radiolabeled imaging agents that bind to targets in the body, which are then imaged with a specialized detector.

An investigational imaging agent, if approved, could one day contribute to patient management by helping clinicians direct biopsies and cancer therapies.

It could be used to track red blood cells to diagnose blood diseases, spread imaging agents throughout the body to visualize atherosclerotic plaques or blocked arteries, or neutralize the immune system before transplants by blocking antibodies that enter the bloodstream.

Another project enabled the first FDA - approved imaging agent that could be used in PET scans of Alzheimer's patients who were still alive.

«With molecular imaging, we are able to see whether the DOTATOC imaging agent is taken up by the tumor.

Sakuma S, Kumagai H, Shimosato M, Kitamura T, Mohri K, Ikejima T, Hiwatari KI, Koike S, Tobita E, McClure R, Gore JC and Pham W. Toxicity studies of coumarin 6 - encapsulated polystyrene nanosphere conjugated with peanut agglutinin and poly (N - vinylacetamide) as a colonoscopic imaging agent in rats.

the biggest barrier to commercialization of nanoparticle - based imaging agents is their development cost.

This includes - but is not limited to - PET / CT, contrast agents for MRI, fMRI, CT and U / S, plus all optical imaging agents.

The new imaging agent offers a non-invasive method of detecting infection and monitoring antibiotic therapy.

Finally, our peptides have been used by other groups to deliver conjugated imaging agents, drugs and nanoparticles to Eph receptor - positive tumors.

He was introduced to radiopharmaceutical development as a postdoctoral research associate and then as a staff scientist in the department of radiology at Washington University School of Medicine, where he developed several preclinical imaging agents to study brain tumors, atherosclerosis and Alzheimer's disease.

We hypothesize that PARP - 1 expression is variable in ovarian cancer and can be quantified in primary and metastatic disease using a novel PET imaging agent.

Studying heparanase - a key enzyme in the development and metastasis of human cancers — scientists unveiled new fluorescent imaging agents that detect enzyme activity in healthy and diseased tissues.

In the featured article from the February 2017 issue of the Journal of Nuclear Medicine, researchers document the first - in - human application of a new imaging agent to help find prostate cancer in both early and advanced stages and plan treatment.

Lantheus Holdings Inc.'s shares are headed for one of their biggest losses since the maker of medical - imaging agents and products went public in June 2015.

Chiu and Kelly were involved in the development of a compound called P53, a key component in an imaging agent called Myoview which went on to generate global...

More data are needed to understand its clinical value but, if results are favorable, this imaging agent could play a critical role in the standard of care for prostate cancer.»

In the study, the imaging agent — Ga - 68 prostate - specific membrane antigen (Ga - 68 PSMA)-- used with positron emission tomography and computed tomography (PET / CT), changed management in 44 % more cases than another widely used agent.

The team plans to complete safety testing of the imaging agent during the next three years.

In their current study, described online today in Science, Discher and his colleagues copied short snippets of the CD47 protein, known as peptides, and attached them to nanoparticles designed to ferry either imaging agents or anticancer compounds to tumors.

What makes this technique novel is the accompaniment of an imaging agent known as Ga - 68 DOTATOC, which binds to somatostatin receptors in neuroendocrine cells that use the hormone somatostatin to mediate endocrine function, the release of neurotransmitters and cellular proliferation.

To bypass this issue, Scott developed a nanocarrier using self - assembled, filament - shaped nanomaterials, which are loaded with a drug or imaging agent.

Results showed that 29 patients» scans revealed strong - binding metastases with a high affinity for the imaging agent.

Specifically, the imaging agents developed in the laboratory for use in fluorescence molecular tomography, are now even being translated into the clinic for human diagnostic applications.

This work confirms the translational potential of a PARP - 1 PET imaging agent and supports future clinical trials to test PARP - 1 expression as a method to stratify patients for PARP inhibitor therapy.

The imaging agent, called fluselenamyl, showed an improved clarity in PET scans of mice and human brain tissue by binding more effectively to the main components of amyloid plaques, a sign of Alzheimer's.

Reston, VA (Scicasts)-- Researchers have developed a new imaging agent that could help guide and assess treatments for people with various neurological diseases, including Alzheimer's, Parkinson's, and multiple...

They developed imaging agents for brain scanning — a technique that is rapidly expanding the reach of medical and scientific research — and also provide analytical chemistry support for clinical studies at McLean Hospital.

SEATTLE — An imaging agent discovered by a Washington State University researcher that homes in on prostate cancer will be developed for human clinical trials thanks to a two - year $ 2 million federal Small Business Innovation Research grant.

The SNMMI Clinical Trials Network is dedicated to facilitating the use of ALL imaging agents in multi-center clinical trials of investigational therapeutics.

«A drug, imaging agent or other function can be fused to the meditope and snapped onto any meditope - enabled antibody.»