Vidaza, from Pharmion, was approved for myelodysplastic syndromes, a bone marrow disorder marked by rapidly
dividing immature blood cells that no longer respond to growth - control mechanisms.
Stem cells are
immature blood cells and, in theory, introducing the gene into them should produce a permanent change in that individual's maturing blood cells.
For instance, a sudden change in the number of reticulocytes, or
immature blood cells, might provide indirect evidence that an athlete has used erythropoietin (EPO), a hormone that stimulates the generation of red blood cells and boosts the oxygen - carrying capacity of the blood.
Stem cells (
immature blood cells) are removed from the blood or bone marrow of the patient (autologous transplant) or a donor (allogeneic transplant) and are frozen and stored.