Sentences with phrase «immature myeloid»

The specific type of cells the researchers in the new Nature Medicine paper looked at, and identified as giving rise to suPAR, are bone marrow GR - 1lo, Sca1 + immature myeloid cells.

Now, researchers at The Wistar Institute have discovered how STAT3 behaves in immature myeloid cells known as myeloid - derived suppressor cells (MDSCs), and they believe they have found the basis for a much more effective method of using STAT3 inhibitors to stop cancer progression in its tracks.

«These immature myeloid cells appear as a main source of circulating suPAR,» says Jochen Reiser, MD, PhD, principal investigator and senior author of the study presented in Nature Medicine, who has been working on solving the mysteries of suPAR for more than a decade.

Reiser's team used a «humanized» mouse model that utilizes patients» peripheral blood stem cells to communicate signals to mouse bone marrow immature myeloid cells.