One does find a large number
of immature red blood cells (regenerative anemia) because the body sends them into circulation prematurely to make up for those that are lost to the disease.
«I tend to scrutinize reticulocyte
[immature red blood cell] values,» Ashenden says, «to see if there are any signs of accelerated or decelerated reticulocyte production.»
He took advantage of an observation made by Alfred Goldberg of Harvard Medical School, who had shown that extracts of
immature red blood cells require ATP to break down abnormal proteins.
Since this disorder does not stop the production of red blood cells, there are
usually immature red blood cells in the bloodstream which can be detected on the blood smears as well (a regenerative anemia).
Especially telling is the «off - score,» the ratio of hemoglobin to reticulocytes, or
immature red blood cells; the ratio increases when blood is withdrawn and infused, making blood doping easier to detect indirectly.
The complete blood count (CBC) from cats with heartworm infection may demonstrate anemia, nucleated erythrocytes (
immature red blood cells), eosinoophila (increase number of eosinophils, a type of white blood cell) and basophilia (increase number of basophils, a type of white blood cell).
Tests may include a reticulocyte test to detect the number of reticulocytes (
immature red blood cells) that are present in the bloodstream, antibody tests such as a Coombs test, or serologic blood tests to detect Feline Leukemia, FIV or parasitic diseases such as Mycoplasma haemofelis.