Ventricular volume was estimated to increase by 1.44 mL (95 % CI, 0.71 — 2.16 mL) in the year immediately before disease onset and by 1.57 mL (95 % CI, 0.93 — 2.20 mL) in the year
immediately after onset; the difference was explained by the acceleration of 0.13 mL per year2 (95 % CI, 0.024 — 0.24 mL per year2; P =.02).