Sentences with phrase «immune activation become»
«This is not, in my mind, an approach to take during chronic infection, because once infection has been established, the mechanisms of immune activation become much more complicated,» observes Martin Markowitz, staff investigator at the Aaron Diamond AIDS Research Center in New York City.
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«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.
So you can see a very clear mechanism whereby people with chronic immune activation can become depressed.»
Initially the innate immune system protects the tissue against these triggers, but prolonged activation becomes self - perpetuating, causing brain cell death to occur.
Without such activation by recognition of infection, Janeway suggested that the adaptive immune system ignored or even became tolerant to the antigens presented by the «quiescent» DC.
Follow - up studies will look more closely at what length of time immune activation starts to become a problem and what mechanisms are responsible for both the improvement and eventual worsening of Alzheimer's pathology.
The detrimental effects of chronic immune activation, which is the result of HIV infection, have become increasingly clear.