Sentences with phrase «immune activation produces»

Perinatal immune activation produces persistent sleep alterations and epileptiform activity in male mice Missig G, Mokler EL, Robbins JO, Alexander AJ, McDougle CJ, Carlezon WA.

Maternal and early postnatal immune activation produce dissociable effects on neurotransmission in mPFC - amygdala circuits Li Y, Missig G, Finger BC, Landino SM, Alexander AJ, Mokler EL, Robbins JO, Manasian Y, Kim W, Kim KS, McDougle CJ, Carlezon WA Jr., Bolshakov VY.

Not exact matches

«While previous studies at McLean and elsewhere have focused on the behavioral symptoms produced by such immune activation, this study goes deeper, going to the cellular level to show how the brain's neural circuits are affected.»

These include pro-inflammatory T helper cells, or Th1, that produce interferon - γ and interleukin - 2, or IL - 2; anti-inflammatory Th2 cells that produce IL - 4, IL - 5 and IL - 13; pro-inflammatory Th17 cells that secrete IL - 17; and immunomodulatory regulatory T - cells, or Tregs, that globally suppress activation of immune responses.

To determine whether early postnatal immune system activation can produce these types of effects, McLean researchers treated mice with a lipopolysaccharide (LPS), a chemical that simulates a bacterial infection and causes a temporary (1 - 3 day) activation of the immune system.

Carlezon, who is a professor of psychiatry at Harvard Medical School, and his team discovered that temporary immune system activation shortly after birth produced two main findings in the adult mice.

«While there are clearly other factors that can cause these types of abnormalities, including genetic vulnerabilities, demonstrating that immune activation alone can produce these effects offers new hope for treatments that might reduce their severity, or prevent them altogether, in certain individuals.»

«The inflammasome in turn activates the enzyme caspase - 1, which then produces two proteins (IL - 1β and IL - 18) that play important roles in the GI tract, including activation of immune cells, induction of antimicrobial peptides, and regulation of epithelial cell proliferation.»

Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.

So were the immune homing signals that are produced as a result of NFkB activation.

activation of NK cells / monocytes in elderly While the researchers found people older than 65 tended to have weaker antibody responses to vaccination, there were common elements of molecular signatures that predicted strong antibody responses in younger and older volunteers. However, elderly volunteers tended to have stronger signatures from immune cells that are not directly involved in producing antibodies (monocytes and â $ ˜natural killerâ $ ™ cells), both at baseline and after vaccination.

The research showed evidence that in rhesus macaques infected with simian immunodeficiency virus (SIV), the monkey form of HIV, loss of IL - 17 producing CD4 + and CD8 + T cells was associated with damage to the colon epithelium and with immune activation (see Monkey Matters, IAVI Report, Nov. - Dec.

More recent research describes adenosine as «a mediator with multisystemic effects», and it is produced by almost all cells, playing a role in heart function, sleep, bone health, activation of the immune system and mediating the effect of various hormones.

APS (also known as astragalus polysaccharide) has been shown to activate the immune system by enhancing the transformation of T lymphocytes (a sub-type of white blood cells, crucial in the regulation of immune responses), as well as the activation of B lymphocytes (which produce antibodies that are used to attack invading bacteria, viruses, and toxins) and dendritic cells, which trigger immune reactions to toxins.