Sentences with phrase «immune cell»

«Bone marrow failure syndromes are problems of blood and immune cell production,» he added.

Contact between a microglial immune cell (purple) and a neuron (yellow), with signaling particles being interchanged

One finding was that strep eventually led to massive production of a certain kind of immune cell, Th17, along with inflammation of the brain.

Blood tests showed that IL - 7 curbed the production of SOCS3 in a type of immune cell called a T - cell, thereby boosting T - cell response.

«Potential to predict peanut allergy immunotherapy outcomes: Successful immunotherapy induces changes in immune cell subtypes.»

«A personalised immunotherapy was prepared for each patient by taking a sample of their blood and extracting a particular type of immune cell called dendritic cells.

Then immunotherapy firm Juno Therapeutics shook hands with gene - editing start - up Editas to create anticancer immune cell therapies; Vertex Pharmaceuticals and Crispr Therapeutics, another start - up, inked an agreement that could be valued at $ 2.6 billion; while Regeneron Pharmaceuticals formed a patent licence agreement with ERS Genomics, which holds the rights to the foundational Crispr intellectual property from Emmanuelle Charpentier, one of the Crispr pioneers.

Asthma has been correlated with an overabundance of one type of immune cell called M2 macrophages in the lungs.

From a simple blood draw, the test reads the DNA of the patient's immune repertoire to find the immune cell barcodes associated with the cancer.

Eight days later, the mice were injected with human interleukin - 7 (IL - 7)-- an immune cell protein — or a placebo, once a day for three weeks.

OX40 functions as a throttle for T cells, another type of immune cell crucial for battling tumors, and the anti-OX40 antibodies rev up these cells.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

Nagoya University - led research team shows in mice the potential of a special immune cell that targets a key protein in tumor growth that helps stop brain cancer.

In the second Cell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuals.

«Every blood and immune cell in our body descends from blood stem cells,» he said.

Researchers also found a type of immune cell (multinucleated macrophage giant cells) in the ovaries of reproductively «old» mice only.

This sparked my interest in the role of one type of immune cell — dendritic cells — in GVHD, and I thought this could constitute a postdoc project.

Their paper, which appears in Nature Communications, describes how an immune cell recruited to the tumor induces the programmed suicide, or apoptosis, of the killer T cells harnessed by many immunotherapies.

The cells are a recently discovered type of immune cell called Th17.

The scientists zeroed in on a type of immune cell called regulatory T - cells, which were known to suppress autoimmune responses.

The males also had fewer nerve cells in their brains and their brains contained a type of immune cell that shouldn't be present there.

New research from Australian and Singaporean scientists has revealed how immune cell «spies» are created, providing clues on how the immune system could be manipulated to better fight disease.

«Scientists find potential mechanism for deadly, sepsis - induced secondary infection: Sepsis disrupts immune cell recruitment to infected skin in mice.»

The service also allows for characterization of all major immune cell types and detects infiltrating immune cells.

We found that: a) lactation stage must be defined biochemically (such as Na: K ratio), not by day of lactation, b) lactation stage influences RNA quality, quantity, and potential immune cell contamination, c) immediate processing and hard, fast centrifugation yield better quality RNA, and d) additional washing of the milk fat layer is not necessary for the analysis of mature milk samples and does not decrease immune cell contamination in colostrum samples.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

Basically, CAR - T therapy involves taking a patient's own immune «killer» T - cells, inserting new genetic code into those cells which turn them into cancer - hunters that can home in on malignant B - cells (another kind of immune cell), and then pumping these specialized leukemia - busting cells back into the patient.

The Food and Drug Administration (FDA) on Tuesday gave Swiss drug giant Novartis a second approval for its pioneering CAR - T cancer therapy, which uses patients» own immune cells (re-engineered outside the body and then replicated) to destroy blood cancers.

If the pathogen or parasite gets by these immune cells, it may successfully invade the mosquito salivary glands.

So research teams began souping up various types of immune cells and even targeting them to specific protein markers on tumors.

Today his company is developing a new cancer vaccine technology that teaches immune cells how to recognize and remove tumor cells.

The athletic adults also appeared to have healthier and younger - looking immune systems, at least when it came to an organ called the thymus that's responsible for generating key immune cells called T cells.

The drug was a single infusion of a patient's own immune cells that have been modified reprogramed to attack their deadly cancer.

Cancer - focused CRISPR technology involves taking a set of molecular shears and the guiding molecule Cas9 in order to cut out unwanted genes in immune cells that may help proliferate cancers.

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

Speaking of Novartis — the company's experimental CTL019, which is expected to be the first approved drug in a revolutionary new cancer treatment space that turns the body's own immune cells into cancer - killers, is already facing some apprehension from doctors and patient groups who are worried about its eventual pricing.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

Gilead subsidiary Kite Pharma (which the biotech giant scooped up ahead of the FDA's approval for Yescarta, a treatment that reengineers patients» immune cells to fight cancer) will have access to Sangamo's platform technology, which could be used to create various types of cancer cell therapies.

CRAC channels are found on many cell types, including immune cells and pancreatic acinar cells, where aberrant activation of these channels is thought to play a key role in the pathobiology of acute pancreatitis.

CAR - T cell therapy is a form of immunotherapy, a rapidly developing cancer treatment that uses patients» own immune cells to attack tumors.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Swiss pharmaceutical giant Novartis has made waves with a drug pipeline that includes one of the most talked - about experimental cancer therapies in recent years — a treatment called Kymriah that reconfigures the body's own immune cells to become aggressive blood - cancer killers.

giant Novartis has made waves with a drug pipeline that includes one of the most talked - about experimental cancer therapies in recent years — a treatment called Kymriah that reconfigures the body's own immune cells to become aggressive blood - cancer killers.

It's the second approval for this pioneering approach to cancer treatment, which involves re-engineering patients» own immune cells to become cancer killers, after the FDA's approval of Novartis» Kymriah in August.

The biotech has been jockeying against main rivals Novartis and Juno to secure a first - to - market advantage with the groundbreaking new medical tech, which turns patients» immune cells into souped - up, re-engineered cancer killers that are then reintroduced into the body.

In 2014, the company raised $ 304 million to fund its experimental cancer treatments that use a person's own immune cells.

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

Gilead Sciences is contracting with Verily Life Sciences, part of Alphabet and a sister company to Google, to research immune cells in the hopes of...