Sentences with phrase «immune cell destruction»
Sophisticated cell targeting systems such as the gene therapy approach developed for senescent cell clearance by Oisin Biotechnologies could also be turned to stem cell or immune cell destruction, given suitable markers of cell chemistry.
https://www.fightaging.org/ Not exact matches
A molecule that helps cancer cells evade programmed self - destruction, an internal source of death, might also help malignant cells hide from the immune system, an external source of death.
The researchers showed that the synapse - eating process requires a protein in the complement system — a part of the immune response that helps «tag» unwanted cells and other debris for destruction.
Checkpoint inhibitors block that handshake, which alerts immune cells to cancer cells and target them for destruction.
Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system's destruction of the beta cells in the pancreas.
In particular, it has evolved to show itself three to nine months after infection, allowing its own destruction by displaying antigens on its cell surfaces so the dog's immune system can destroy it.
This is an illustration of how the engineered protein facilitates destruction of latently HIV - infected immune cells.
This is characterised by the targeted strengthening of the body's own immune cells, unlike in chemotherapy, in which the aim is direct destruction of the cancer cells.
Slusher teamed up with Johns Hopkins Kimmel Cancer Center immunologist Jonathan Powell, M.D., Ph.D., who has studied how cancer cells use different metabolic pathways to evade destruction by immune cells.
Among the protagonists are B cells, which produce antibody molecules able to neutralize pathogens or mark them for destruction, and T cells, which prompt infected cells to kill themselves or secrete chemicals that direct the activities of other immune players.
Therefore, these «self - reactive» T cells survive destruction within an organ called the thymus, the central immune organ in which T - cells mature, and attack healthy cells and tissues, including melanocytes.
«Not only did we confirm that the presence of blood in the brain recruits peripheral immune cells to the area, which is sufficient to cause myelin destruction, we also identified fibrinogen as the critical protein driving this process.»
If the T - cells miss their target or if they mistakenly order the destruction of a healthy cell, the result will be disease in the form of infection, cancer, allergies or auto - immune conditions.
Such neoantigens are foreign to the immune system, and thus, the cancer cell is flagged for destruction, usually with the help of immunotherapy drugs.
By attaching to the myeloma cells, it marks them for destruction, and by attaching to NK cells, it primes the immune cells to search for and attack the myeloma cells
The selective pressure of the competent immune system «edits» the tumor by selecting for cells that can avoid immune destruction.
Further, they present two new hallmarks — reprogramming of energy metabolism and evasion of immune destruction — that have emerged as critical capabilities of cancer cells.
This draws the innate immune system's natural killer (NK) cells into the fray, promotes the antibody - mediated destruction of malignant cells and, ultimately, supports the activation of T cells that specifically target the cancer.
«The destruction of red blood cells outside of vessels by immune cells in PNH has long been speculative due to limited experimental evidence.»
This enhances the immune response through multiple mechanisms: by attaching to the myeloma cells, it marks them for destruction, and by attaching to the NK cells, it primes the immune cells to search for and attack the myeloma cells.
Researchers have discovered that a subset of human antibodies have catalytic activity against a particular antigen, breaking it down into smaller and less harmful fragments instead of trapping it for removal or destruction by other immune cells.
Interestingly, when parental d42m1 sarcoma cells were transplanted into wild - type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).
These «surface proteins» are easily recognized by the immune cells and targeted for destruction.
The high doses of therapy lead to the destruction of a patient's own marrow and immune system, which is then replaced by marrow from a donor or from peripheral blood stem cells that have been harvested before therapy.
Specifically, some tumor cells appeared to express PD - L1, essentially «wrapping» themselves in it to avoid immune recognition and destruction.
When implanted, PEC - 01 cells are expected to differentiate into pancreatic islet cells that produce insulin and other hormones that regulate blood sugar, while the Encaptra device is designed to protect the cells from immune destruction.
One of the main reasons cancer remains difficult to treat is that cancer cells have developed a multitude of mechanisms that allow them to evade destruction by the immune system.
Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral tolerance to arrest autoimmune responses (31).
The cells in the immune system responsible for this auto - destruction are called TH - 17 cells.
The common identifying factor in most autoimmune diseases is a destructive processes called inflammation which will eventually cause the destruction of cells and tissues specific to the type of auto - immune disease he person has.
While dogs tend to develop diabetes mellitus secondary to either immune destruction of the pancreatic beta cells or severe pancreatitis, cats tend to develop diabetes mellitus secondary to pancreatitis or amyloidosis.
The third stage of the infection results from a progressive destruction of the white blood cells and dysfunction of the immune system.
IDDM can also be triggered by infectious virus diseases, immune deficiencies that result in destruction of the insulin - producing cells in the pancreas, pancreatic infections, steroids and reproductive hormones, and Cushing's disease.
There are a few less - often used: Valbazen (albendazole) is about 90 % effective in removing cysts but has been implicated in birth defects, suppression of the immune system, and destruction of red blood cells.
Along with myasthenia gravis, other canine diseases that can be treated with plasmapheresis include lupus and immune - mediated hemolytic anemia, which causes the premature destruction of oxygen - carrying red blood cells.
There are a number of causes of anemia in dogs, such as excessive internal bleeding or destruction of red blood cells arising from infections or exposure to toxins (medicines and household products metals such as zinc), but the most common cause is a disease called immune mediated hemolytic anemia (IMHA).
This discoloration is the result of excessive bilirubin in the bloodstream, which can be the result of either backed up liver circulation due to disease, or as the result of excessive accumulation of bilirubin due to the destruction of red blood cells caused by a disruption in red blood cell metabolism, a defective immune system, or both.
At least 50 % of diabetic dogs have type 1 diabetes based on present evidence of immune destruction of β - cells.
The etiology of β - cell destruction in diabetic dogs is often unknown, although there is evidence that it is frequently caused by immune - mediated processes similar to human type 1 diabetes (70 — 72,82 — 84).
We will identify an ITP disease profile by measuring immune cells and proteins that may be involved platelet destruction.
Our project aims to investigate the specific causes of ITP by identifying an ITP disease profile by measuring immune cells and proteins that may be involved platelet destruction.
In dogs, Diabetes is thought to be an immune mediate disease process causing destruction of the cells in the pancreas responsible for the production of insulin [3].
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)
Lymphocytic thyroiditis, probably immune - mediated, is characterized histologically by a diffuse infiltration of the gland by lymphocytes, plasma cells, and macrophages and results in progressive destruction of follicles and secondary fibrosis.
In addition to affecting the GI tract, parvovirus also attacks your dog's immune system, resulting in panleukopenia, or destruction of disease - fighting white blood cells.
The pathogenic mechanisms responsible for decreased insulin production and secretion are multiple, but usually they are related to destruction of islet cells, secondary to either immune destruction or severe pancreatitis (dogs) or amyloidosis (cats).