Sentences with phrase «immune cell differentiation»

Having discovered a genetic «key» (called P - TEFb) that is important in both cancer cell growth and immune cell differentiation, they tested the drugs on a mouse model for uveitis, an incurable eye condition in which the immune system mistakenly attacks healthy tissue leading to inflammation of the uvea (the middle layer of the eye).

Liew was first to demonstrate roles of nitric oxide within the immune system, both in the process of killing engulfed pathogens and regulating immune cell differentiation.

Not exact matches

The release of several signals by skin cells that are dying contributes to the creation and spreading of the chronic immune response and hyper - proliferation and irregular differentiation of epidermis,» says Joan Manils, first author of the study and member of the mentioned department and post-doctorate researcher at the Trinity Biomedical Sciences Institute (Ireland).

A group of researchers at Immunology Frontier Research Center (IFReC), Osaka University and RIKEN Center for Integrative Medical Sciences jointly clarified the mechanism for inducing germinal - center B cells» differentiation into memory B cells, immune cells that remember antigens, at the molecular level.

«Mechanism for inducing memory B cell differentiation elucidated: Efficient induction of immune cells that remember antigens will lead to the development of new vaccines.»

One likely reason for this is that animals undergo cellular differentiation; human life begins as a single cell that differentiates into the various cell types needed for different organs, body parts, blood, the immune system, etc..

JAK1 is part of a well - studied regulatory network of proteins that is involved in the control of cell growth, differentiation, apoptosis, inflammation, and immune response.

Wu, who is also a professor of cardiovascular medicine and of radiology, said, «This study certainly makes us optimistic that differentiation — into any nonpluripotent cell type — will render iPS cells less recognizable to the immune system.

Since then, Ohsumi and others have shown that autophagy plays a crucial role in embryo development, cell differentiation, and the immune system.

Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).

Now, a collaboration between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep cells in a multipotent stem cell - like state where they can continue to proliferate and can later differentiate into various cell types.

Even though STAT3 activity drives the expansion of MDSCs and is involved in immune responses mediated by the cells, they found that high levels of STAT3 activity actually prevent the differentiation of MDSCs to macrophages.

Interaction of human mesenchymal stem cells with cells involved in alloantigen - specific immune response favors the differentiation of CD4 + T - cell subsets expressing a regulatory / suppressive phenotype.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

Histone deacetylases (HDACs) are critical for the differentiation and immune function of T cells (17 — 19).

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

Because Akt is an important factor in the differentiation and immune function of T cells, and previous studies showed that VPA and other HDAC inhibitors could inhibit Akt activity in cancer cells (41, 42), we examined whether Akt activity was modulated by VPA treatment.

Therefore, our results suggest a direct suppressive effect of VPA on the differentiation and immune function of Th1 and Th17 cells.

«The observed increase in the ratio of cytotoxic CD4 T cells to CD4 helper T cells indicates that they are an important component of the protective immune response to viral infections and that their induction should be an important marker for successful vaccinations against certain viral diseases,» says postdoctoral researcher and first author Veena Patil, Ph.D. «But we really didn't know enough about their molecular profile and the mechanisms that drive their differentiation and maintenance.»

VPA suppresses Th1 and Th17 cell differentiation and immune function in vitro and in vivo through direct inhibition of Akt.

Sphingosine -1-phosphate is a potent signaling lipid involved in numerous biological functions including, cellular proliferation, survival, migration, invasion, differentiation, architecture, immune cell trafficking, angiogenesis and vascular integrity.

He has been a leader in applying molecular and genetics tools to study the immune system including specification of T lymphocyte lineages, the differentiation of inflammatory T helper cells, the role of microbiota in regulating immune responses, and the mechanisms of HIV entry and pathogenesis.

Differentiation of naïve CD4 ⁺ T cells into functionally distinct T helper subsets is crucial for the orchestration of immune responses.

Because the same pool of naïve T cells can differentiate into inflammatory effector T cells or inhibitory Tregs, generation of immune responses requires promoting the differentiation of inflammatory T cells while reciprocally inhibiting the formation of Tregs.

Vitamin D is necessary for maintaining proper calcium balance, proper immune system function, insulin secretion, blood pressure regulation, and cell differentiation (specialization of cells for particular functions.

Clinical and laboratory research has shown that certain herbs can support normal function of the liver, kidneys, heart and immune system; reduce inflammation and improve blood flow through damaged tissues; promote the differentiation, aging and death of tumor cells; and reduce pain.