Sentences with phrase «immune cell infiltration»

Here we present a novel human Airway Lung - Chip containing a fully - differentiated human mucociliary airway epithelium separated from a pulmonary microvascular endothelium by a semi-permeable membrane that allows for immune cell infiltration.

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis.

To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000 tumor tissue samples, from both before and after treatment, looking for clues regarding how treatment outcomes relate to immune cell infiltration into tumors.

In this study, immune cell infiltration of the lungs increased, and Th2 responses became more prominent.

Not exact matches

That reaction results when a localized accumulation of immune complexes — antibodies bound to their antigens — is deposited in tissue and sets off an inflammatory response involving the infiltration and activation of immune cells, initially the neutrophil.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

However, tumor cells can circumvent this immune defense by establishing a surrounding microenvironment that prevents the infiltration of NK cells and thus promotes tumor survival and growth.

In addition, older tissues tend to exhibit more chronic inflammation — a low - level infiltration of immune cells and substances.

Cortisone helps to enhance the barrier function of the endothelium, preventing vascular leakage and further infiltration of the alveolar space by immune cells.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

The brain is generally considered an immune - privileged environment and immune cell leukocyte infiltration is known to be tightly regulated [21], [22].

Moreover, the increase in leukocyte infiltration is most striking when considering the total numbers of CD4 and CD8 T cells, providing further evidence for a T cell - mediated immune response in the brain and / or meninges following infection with attenuated Type I parasites (Figure 3F).

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

The most common cause of inadequate tear secretion is the infiltration of inflammatory cells from the immune system into the cells of the lacrimal gland.

The underlying pathology involves infiltration of the bowel wall by inflammatory cells due to altered immune system function.

Lymphocytic thyroiditis, probably immune - mediated, is characterized histologically by a diffuse infiltration of the gland by lymphocytes, plasma cells, and macrophages and results in progressive destruction of follicles and secondary fibrosis.