Sentences with phrase «immune cell interactions»
We will assemble leading experts to discuss basic immunology, cancer - immune cell interactions, and examine how tumor - associated inflammation can be reprogrammed for therapeutic benefit.
http://www.cell-symposia.com/ Not exact matches
«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.
Interaction between the PD - 1 protein found on killer T cells and its binding partner PD - 1L is one hallmark of immune exhaustion, and interfering with this interaction a potential strategy to overcome it.
«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»
These interactions allow HIV to spread efficiently between these immune cells, known as CD4 + helper T cells.
But exactly how the immune system works remains, in many ways, a mystery, as there are numerous cell types whose functions and interactions with our immune systems have not been well understood.
Learn about the latest approaches to assessing cancer - immune interactions («immune profiling») using FFPE tissue sections, multiplexed immunofluorescence, and cell phenotyping software
This is an illustration showing interactions between components of the AH10 - 7 compound (yellow), an immune system antigen - presenting cell (gray), and an invariant natural killer T cell (green and blue) that spark activation of iNKT cells in «humanized» mice.
Their interaction prevented first - responder immune cells, called macrophages, from triggering reactions that kill cancer cells.
Inhibiting this interaction blocked the autoimmune process, stopping the microglia from signaling to the peripheral immune cells and averting myelin damage and inflammation.
She is currently at Rockefeller University, where she is studying the interactions between immune cells and stem cells in an effort to develop stem cell - based therapies for inflammatory disorders.
Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human cancers.
The importance of this interaction between ILC3s and T cells for the immune defense was shown in mice that were lacking the MHC molecules on their ILC3s.
«Communication between lung tumors, bones contributes to tumor progression: Study identifying interaction among tumor cells, bone marrow and immune cells opens new avenue for immunotherapy.»
The results, revealing new examples of heritable bacterial species — including those related to diet preference, metabolism, and immune defense — appear May 11 in Cell Host & Microbe's special issue on the «Genetics and Epigenetics of Host - Microbe Interactions.»
She is currently at Rockefeller University, where she is studying the interactions between immune cells and stem cells in an effort to develop stem cell — based therapies for inflammatory disorders.
This searching process involves short, «touch - and - go» interactions between the platelet and Kupffer cells (blue), a specialized immune cell that lives in the blood vessels of the liver.
Hence, we merged our expertise in evolutionary biology and immunology to study the complex interactions between the vertebrate immune system, composed of a myriad of different cells, and the gut microbiota, composed of another myriad of different bacteria.
They found that the interaction of the C3dg fragments on affected erythrocytes and the binding domain for CR3 on immune cells can lead to phagocytosis and the rupturing of red blood cells in PNH patients.
Through a number of immune interactions between T cells and B cells, B cells produce allergen - specific IgE antibodies.
With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).
Research Interests: Inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; animal models of IBD; mucosal T - cell death and survival; tolerance to gut microbiota; interactions between immune and non-immune cells; immune - driven angiogenesis and lymphangiogenesis; intestinal fibrosis; intestinal myofibroblasts, extracellular matrix; systems biology; complex diseases
In addition, some of the most important interactions between innate immune cells and these pathogens occur in the tissue and not in peripheral blood, which by necessity is the compartment on which most HIV and TB research is based.
Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.
Through understanding the biology of cancer cells and their interaction with the immune system we are able to discover and trial novel therapies to induce the immune system to detect and fight cancer cells.
Cutting edge: differential segregation of the SRC homology 2 - containing protein tyrosine phosphatase - 1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions.
This novel approach, which reveals complex interactions between cells and proteins, can also be used for other diseases to generate new knowledge about the regulation and dysregulation of the immune system, which can eventually give rise to new, improved immunological therapies.
The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.
Her studies there focused on investigating host - pathogen interactions between Mycobacterium tuberculosisand pulmonary immune cells during the early stages of infection.
Our general aim is to understand the reciprocal interactions between immune cell state / behavior and their environment -LSB-...]
Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels
We obtained a molecular signature that really pointed us in a very specific direction which is looking at the interaction between the degenerating neurons and local, innate immune cells that are responding to early injury and stress in the neurons.
Cell wall components and secreted proteins show the greatest variation, indicating their potential role in host - bacillus interactions or immune evasion.
• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.
Taking the microbiome into account may be important for accurate phenotype - genotype analysis due to the increasing awareness of the impact the microbes have on different body sites, through the products they produce, their ability to protect against invading organisms, their direct interaction with the cell structures and the extracellular milieu, provoking inflammatory or immune responses, and many other effects.
Conclusions: In an analysis of peripheral blood mononuclear cells and intestinal tissues from patients with inflammatory bowel diseases vs controls, we found that reactivity to intestinal bacteria is a normal property of the human CD4 + T - cell repertoire, and does not necessarily indicate disrupted interactions between immune cells and the commensal microbiota.
The new work focuses on the regulation of immune response by two forms of the signaling molecule IL - 8, as well as IL - 8's interaction with cell - surface molecules called glycosaminoglycans (or GAGs for short).
Dr. Locksley's laboratory focuses on tracking cytokine expression in model systems, as a mechanism to investigate complex functional interactions between innate and adaptive cells in the immune system.
The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors.
The goal of this work is to develop novel therapeutic targets based on increased understanding of the interaction of tumor cells and immune cells.
Tumor cells constantly alter their metabolic state in response to oncogenic stimuli, nutrient availability, and interaction with immune cells however the precise regulation that precedes the metabolic alteration is poorly understood.
While it is true that metabolic «errors» typically build up inside the genetic machinery of «pre-cancerous» cells and play a primary role in the development of cancer, it is also true that dysfunction in our immune system, inflammatory system, hormonal system, detoxification system, and antioxidant system — and problematic interactions between these five systems — can significantly increase the risk of cells becoming cancerous.