Not exact matches
Researchers in the Departments of Biomedicine and Nephrology at the University Hospital and the University of Basel have discovered that the
immune system uses a molecular biological clock to target intolerant T
cells during their
maturation process.
Understanding which cytokines are best for monitoring inflammation and immunosuppression, and knowing which are secreted by different
immune cell types at each stage of
maturation and activation, will provide essential insights into disease treatment options.
Which cytokines are secreted by different
immune cell types following
maturation and activation
ICOS gets antibody production started by promoting the
maturation of Tfh
cells, which migrate into compartments or follicles of
immune organs such as spleens and lymph nodes, which themselves are full of B
cells.
Of special interest were ICOS, whose «role in effector T
cell responses and anti-tumor
immune responses is now well established,» and CD40, which is «important for the
maturation of antigen - presenting
cells and for enabling T
cell co-stimulation.»
By combining new systems biological analyses and advanced data analysis, a recent study led by Petter Brodin (Karolinska Institutet / SciLifeLab) have been able to monitor the
maturation process of the
immune system in leukaemia patients who have undergone stem
cell transplantation.
A new paper published in the February 2018 issue of Immunity by La Jolla Institute for Allergy and Immunology (LJI) researcher Yun - Cai Liu, Ph.D., reports mechanisms used by a subgroup of ILCs, known as ILC2
cells, to undergo
maturation required for them to mount an effective
immune response.
Folate and iron are essential, too, for healthier red blood
cells while zinc and selenium can help in the
maturation of the
immune system.