Sentences with phrase «immune cell population»

Cell markers are helpful tools used to identify a specific immune cell population.

PER2: Deletion of the PER2 gene in mice, associated with the mechanisms of circadian rhythm, appears to improve DNA repair in stem cell populations relevant to the immune system, resulting in a healhier immune cell population, better immune function in old age, and a modestly extended life span.

Scientists in the six - site study analyzed the tissue in 41 rheumatoid arthritis patients, separating out different immune cell populations.

Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.

Identify immune cell populations with our flow cytometry antibodies and kits and isolate them with our cell selection kits.

«[It] supports this idea that chronic inflammation in children, perhaps through exposure to bacterial endotoxin in the gut, is causing these different immune cell populations to be non-responsive to cytokine stimulation,» Petri said.

Through image analysis of breast tumors and TDLNs, we have found that immune cell populations as well as their spatial distributions and clustering patterns have strong correlation with clinical outcome.

Not exact matches

In that paper, Weitzmann, Ofotokun, and their colleagues described bone loss similar to that observed in humans following the reconstitution of the T cell population in immune - compromised mice (similar to T - cell expansion following ART).

They discovered a population of NKT cells that have a gene that controls so - called regulatory T - cells, whose role is to suppress the immune response.

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T - cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

One plausible explanation was that over the course of successive population crashes, the devils had become so inbred that their cells look identical — at least to the animals» immune systems.

They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

The most commonly reported side effects were a decrease in certain populations of immune cells, conditions called neutropenia and leukopenia, an expected effect that indicates the drug is working.

In a study, researchers found that pigs, which have gut bacterial profiles and immune systems similar to humans, also maintain two distinct colonic stem cell populations — ASCL - 2 and BMI - 1.

First author of the paper, Dr Christian Schwartz, a European Molecular Biology Organization Long Term Fellow in Professor Fallon's group, added: «It is fascinating that a small cell population such as the ILC2s can regulate the expansion of Th2 cells and thereby shape the whole outcome of an immune response — be it beneficial in case of parasitic infections, or detrimental as in the case of allergic responses.»

«By combining the genetic analysis of a small population of immune cells from healthy skin with functional experiments we were able to define two subgroups of memory immune cell and in detail decipher / dissect how these cells behave in healthy and inflamed skin,» explains Liv Eidsmo, researcher at Karolinska Institutet's Department of Medicine.

This population of cells suppresses the growth of cancer - fighting immune cells, thereby limiting the ability of the immune system to fight off cancer.

National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.

Now a team of engineers at MIT has developed a new way to deliver such vaccines directly to the lymph nodes, where huge populations of immune cells reside: These vaccines hitch a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.

When challenged by a toxin or infection, the immune system screens this population for a match, then swiftly multiplies the clonal cell line that produces the matching antibody.

«Ulcerative colitis is often associated with decreased mucus production and the worms seem to somehow restore mucus production, possibly by inducing a population of immune cells that make IL - 22,» Loke says.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

Researchers at Dana - Farber Cancer Institute this year announced that a previously unrecognized population of cells in the lymph nodes signals the immune system to tolerate conditions that would normally prompt an attack.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

A failure of immune cells to keep the gut microbe population in check can lead to chronic gut inflammation, manifesting as IBD.

The difference between these two primates is that the sooty mangabey experiences only low levels of immune activation, which presumably limits the T cell population crash and viral replication.

Antibodies stimulate the recruitment of additional immune cells that help to activate T cells; the vaccine stimulates proliferation of T cells that can attack the tumor; IL - 2 helps the T cell population to expand quickly; and the anti-PD1 molecule helps T cells stay active longer.

AIM2 is present in all immune and epithelial cells, which make up a large part of the intestine's cell population and help to maintain a healthy gut.

In principle, tissue banks of parthenogenetic cell lines could include enough different immune protein combinations to treat up to half of the U.S. population — men as well as women — Lanza says.

In healthy individuals, MDSCs regulate immune responses and tissue repair, and the population of these cells rapidly expands during inflammation, infection and cancer.

One of the most difficult things about treating the virus is that when a person is infected with HIV, it becomes part of the cellular population of that individual's immune cells, according to David Margolis, MD, professor of medicine, microbiology and immunology, and epidemiology at the UNC School of Medicine and director the UNC Cure Center and Collaboratory of AIDS Researchers for Eradication.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these are related to their ability to function similarly to cells of the innate as opposed to the adaptive immune system.

When you're an adult, you have a population of T cells that give you your immune memory for lifetime.

The hallmark of an effective T cell response is the formation of a stable long - lived population of cells that mediate immune memory.

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

The Hematopoietic stem cell population resident in bone marrow is responsible for generating blood cells and immune cells.

PHENOMIN - CIPHE has developed a whole set of standardised protocols constituting PHENOMIN - CIPHE «toolbox», which enables to identify with unparalleled precision, the composition and the activation status of myriads of cell populations constituting of the adaptative and innate immune system.

To define the phenotype and function of specific cellular populations involved in the cross-talk between cancer and immune cells we make use of both flow - cytometry and mass - cytometry.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

Researchers also provided new details of how the Nrp1 pathway functions, including evidence that along with bolstering the ability of regulatory T cells to suppress the immune response, the pathway also helps maintain a stable population of regulatory T cells.

The scientists» studies also showed that AIM2 played a role independent of its immune role, in suppressing abnormal expansion of intestinal stem cell populations.

«Sample multiplexing of peripheral immune populations for high throughput single - cell RNA - sequencing»

Microchimerism is the presence of small populations of genetically disparate cells within a host as a result of transfusion or transplacental trafficking during pregnancy, and may influence immune tolerance in the recipient.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

They should be replaced with new populations, but while simple in concept, and even achieved for some cell types, such as the blood stem cells that produce immune cells, this is easier said than done for the body as a whole.

In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

The tumor microenvironment is comprised of heterogeneous populations of cells including cancer, immune and tumor associated stromal cells.

Here we undertake a synthesis of central concepts for evolutionary predictions, based on examples of microbial and viral systems, cancer cell populations, and immune receptor repertoires.