Sentences with phrase «immune cell receptors»

Dr Andreas Ebneth, project leader at Janssen Pharmaceutica NV, states: «The research project's value is its interdisciplinary approach focused on two relevant immune cell receptors suspected to be involved in Alzheimer's disease.

«Using AI technology to chart immune cell receptor.»

The team used a specific mouse strain that is healthy but it is lacking in a specific immune cell receptor, which makes the mouse unable to reject transplanted foreign cells.

Not exact matches

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

Every cell in the body have vitamin D receptors, which means that D - vitamin is very important for optimal health and the immune system.

Some tumor cells use this receptor to hide from the immune system (SN: 4/1/17, p. 24).

A transformative cancer therapy based on modified immune cells has lured doctors, companies, and patients alike, but many are hitting a frustrating roadblock: generating enough of these chimeric antigen receptor (CAR)- T cells to meet surging demand.

Thomas speculated that as many as 10 percent of T cell receptors are outliers that help the immune system recognize and rapidly respond to mutations that might otherwise help virus - infected cells and other threats delay detection.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

These are receptors on immune cells, which control for example effector T - cells by dampening their activation if damage to healthy cells is imminent.

They identified five receptors closely related to a class of receptor already known to help immune cells hone in on pathogens and inflammation.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

When the researchers added a little of this bacterial byproduct to the mix, Fel d 1 activated a specific immune receptor on cells, called Toll - like receptor 4 (TLR4).

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

«What we think happens is that the bacteria activate immune cells, which release chemicals called cytokines that then act on receptors on the sensory nerves to increase their activity,» he says.

Besides docking to white blood cell receptors called CD4, the scientists found that HIV also enters cells via receptors — such as CCR5 — normally reserved for immune messengers called chemokines.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

The system, says Brahmer, provides a kind of «handshake» or connection between receptors on immune cells, called PD - 1, and their sister - proteins on tumor cells, called PD - L1.

The drug blocks CTLA - 4, a protein receptor on the surface of T - cells that serves as a molecular stop sign, preventing the immune system from going into overdrive.

Activation of these receptors led to a «massive mobilisation» of myeloid - derived suppressor cells (MDSCs), which play a crucial role in lowering the immune system response back down to normal levels (European Journal of Immunology, DOI: 10.1002 / eji.201040667).

THC activated two types of cannabinoid receptor on immune cells, called CB1 and CB2.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

On encountering the TB bacillus, receptors on immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacillus.

The receptor is believed to inhibit the ability of immune cells to autodestruct when they have outlived their usefulness, resulting in higher concentrations of proinflammatory signals (such as TNF) in the intestines of IBD patients.

The result, published January 5 in Science Immunology, suggests that the protein, a receptor involved in immune cell signaling, plays a role in spontaneous abortions and other human pregnancy complications.

«Inflammatory arthritis is caused when immune cells are recruited from the blood into the joint in a highly regulated process controlled by chemoattractants and adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.

The known FPRs include two immune system receptors that detect chemicals given off by pathogens in the blood, helping immune cells track down and attack foreign bodies.

Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils.

Prof. Mandelboim and his research collaborators found that the NKp46 receptor present on Natural Killer or NK cells (an essential part of the immune system) play a critical role in the development of the disease in mice.

Antril, which is classified as an interleukin - 1 receptor antagonist, occupies the site on cells lining blood vessels where interleukin - 1 docks before it triggers an immune response.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

TLR7 is one of a family of receptors present on innate immune cells like macrophages that have been linked to chronic inflammation and autoimmunity.

As part of this system, two enzymes called Rag1 and Rag2 cut apart and rearrange DNA within immune cells, helping to create the body's millions of unique antibodies and T cell receptors — each specific for a particular microbe.

Newly - discovered mechanism of action of the bacterial superantigen toxins: Superantigens bind to both B7 - 2 and CD28, the major costimulatory receptors expressed on human immune cells.

The findings provide new insights into the immune system's T cells, each of which possesses receptor proteins that allow it to recognize a specific pathogen.

To curb attacks on our own tissues, immune cells carry receptors that dial down their activity.

But tumor cells can also stimulate these receptors, preventing the immune system from attacking them.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

The immune system detects viruses when viral nucleic acids bind protein receptors in immune cells.

These receptors detect viral RNA and signal an innate immune response inside the cell that is essential for limiting and controlling viral infections.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Nair found that immune cells exposed to meth make more of these receptors.

Niacin binds its receptors to skin immune cells, causing many of the symptoms patients experience: plethora (engorgement in skin vessels) and rubor (redness of the skin), as well as heat, swelling, pain, and frigor (cold / chills).

Organ transplantation is a challenge, requiring immunosuppressive drugs and careful matching of donor and recipient for human leukocyte antigen markers, receptors on immune cells that recognize foreign proteins.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

The gene codes for an immune receptor on red blood cells; lack of that receptor prevents infection by Plasmodium vivax, a species of the malaria parasite.

Varki studies siglecs, small groups of receptors that thickly stud the immune T cells of monkeys and apes but are few and far between in humans.