Sentences with phrase «immune cell types from»

«Unlike previous studies we isolated different immune cell types from the actual site of disease to determine whether specific subsets of immune cells (specific T cell groups) have equal sensitivity to vitamin D.»

Not exact matches

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

In the second Cell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuCell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individucell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuals.

The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an inherited lipid storage disorder, have a significant increased risk for developing myeloma; and the discovery of a subset of lipid - reactive immune cells, called type II NKT - TFH, that promote the development of plasma cells.

They demonstrated that PS extracts protect blood and immune cells from infection by HIV - 1, the most widespread type of HIV.

It is the stuff of dreams for flu scientists, but it could be within reach if a new type of vaccine that elicits an immune response from white blood cells is combined with traditional vaccines.

The researchers then took naïve immune cells — which transform into different types based on the invaders they encounter — from the blood of healthy individuals and exposed them to bacteria in the guts of MS patients.

Antibodies derived from a type of immune cell found in unusually high numbers in HIV - infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV, scientists report.

To better understand how this abnormal distribution of B cell types in people with uncontrolled HIV affected their immune response to the virus, researchers compared HIV - specific antibodies derived from both TLM and RM B cells.

The researchers studied two types of cells called effector T cells, which activate the immune system to defend our body against different pathogens, and regulatory T cells, which help control the immune system and prevent it from attacking healthy parts of its environment.

During the initial phase, a relatively aggressive inflammation response occurs, and several types of cell from the immune system are attracted to the wound.

It reports that mice rendered immune to dengue show «cross-protection» from subsequent Zika infection and then identifies specific types of immune T - cells capable of defending against both viruses.

To help the new organ withstand the assault from the recipient's natural defenses, doctors developed tissue type matching, a technique to determine if the chemistry of the donor's immune system, defined by antigens on the surface of cells, was similar to that of the recipient's.

In normal immune responses, a second type of helper cells, known as TH2, secrete another batch of cytokines, including one called interleukin - 4 (IL - 4) that turns off the cytokine release from TH1 cells.

Copeland's team also noted that these mice suffered from a host of immune - related problems, the most crippling being a flood of macrophages — a type of white blood cell — damaging the lungs and other organs.

When the scientists blocked Treg cells from accumulating in the fat by targeting a molecule that the immune cells require, mice no longer developed type 4 diabetes in old age.

This study shows that in conditions like toxic shock syndrome, toxins from such bacteria can trigger one type of immune cells (MAIT cells) to turn against the host.

After 3 months, the researchers drew blood samples from the monkeys, purified five different types of immune cells, and measured gene expression across their entire genomes.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

A potential solution to this problem is to reprogram other cell types into functional beta - like cells, which can produce insulin but are distinct from beta cells and therefore are not recognized or attacked by the immune system.

Two teams of scientists suggest that activating immune cells in fat can convert the tissue from a type of fat that stores energy to one that burns it, opening up potential new therapies for obesity and diabetes.

The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.

In patients with severe asthma, however, NK cells are disabled from resolving inflammation, and become outnumbered by other types of immune cells that provoke inflammation.

In the Dec. 1 issue of Science, the team from the MGH Center for Systems Biology describes a «crosstalk» between lung tumors and bone marrow, which leads to the generation of a type of immune cell that travels to the tumor and promotes its progression.

In the newly published study, Mount Sinai researchers from The Mindich Child Health and Development Institute and the Jaffe Food Allergy Institute report that by counting the numbers of one type of immune cell activated by exposure to a food, a simple, safe blood test can accurately predict the severity of each person's allergic reaction to it.

Groundbreaking findings, published online in the journal journal Cancer Cell, show that resistance to many types of antibody drugs can be overcome by preventing cancer cells from «hiding» from immune cells.

Currently, investigators around the world are experimenting with restoring the immune cells responsible for keeping CMV in check by transplanting those specific anti-viral cells from healthy donors — a type of immunotherapy.

In Type 1 diabetes, the immune system attacks the body, destroying pancreatic b cells and preventing the pancreas from producing the insulin.

Johannes Scheid, a student in Nussenzweig's lab, isolated it several years ago from an HIV - infected patient whose immune system had an exceptional ability to neutralize HIV in the blood by preventing the virus from infecting and destroying a specific type of immune cells, called CD4 cells, in patients.

To regain function, connections from the brain to the spinal cord must regrow, different types of immune cells have to clear the injury site, and stem cells in the spinal cord need to generate new nerve cells, which then connect to the muscles.

The bacteria hide within human cells called macrophages, escaping the body's own immune defenses and being shielded from many types of antibiotics.

Researchers from immune biology professor Annette Oxenius's group have now discovered what keeps NK cells from killing off their «colleagues from the other department» of the immune system: healthy CD8 + cells are able to detect the immune messenger substance type 1 interferon, which binds to specific receptors on the surface of these immune cells and thereby conceals their stress.

UH researchers have identified a unique epigenetic footprint in specific types of immune cells from blood that can identify individuals with HIV that have a range of impairments in cognitive function.

A research team, led by Chao Cheng, Ph.D., Assistant Professor in the Department of Genetics at The Geisel School of Medicine at Dartmouth, used gene expression data from breast cancer patients to computationally infer the presence of different types of immune cells.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

Signals from pathogens, tissue factors, and other immune cells are involved in defining the immune phenotype of these cell types.

The notion that CD4 + T cells might be the pivotal mediators of corneal graft rejection arose from studies demonstrating the close correlation between delayed - type hypersensitivity (DTH), a classical CD4 + T cell - mediated immune process, and corneal graft rejection in rodents (10, 11).

Both of the cell types come originally from the blood and can be considered immune cells.

The human immune system contains a collection of different cell types and molecules that help to protect the body from toxins, viral infections, bacteria, and parasites.

NKG2D is a type of immunoreceptor — a molecule present on the surface of the body's immune cells that recognises signals from normal cells that are distressed.

The treatment is designed to stop the immune systems of those with type 1 diabetes, a condition which usually develops in childhood, from mistakenly destroying the cells which create insulin.

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

Normally, two types of immune cells, called T cells and B cells, protect the body from invading viruses, bacteria and fungi.

Examining the genomic and epigenetic makeup of major types of immune cells from nearly 200 blood donors in the U.K., IHEC researchers found that genetics explain most of the epigenetic variation among individuals.

The team analyzed the frequency of different types of immune cells in blood collected from 110 one year - old study participants, the presence of immune - stimulatory components in the subjects» house dust and asked whether any of the factors correlated with an increased of asthma at age seven.

In their latest work, reported online in the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodies.

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

A team of chemical and biomedical engineers from the Cockrell School of Engineering at The University of Texas at Austin, in collaboration with researchers from the University of Pennsylvania, have discovered that HIV - infected patients experience a dysfunction in a certain type of immune cell: the follicular helper T (Tfh) cell.

On the other hand, boosting the ability of Tregs to suppress other types of immune cells could prevent autoimmunity, by preventing these cells from attacking organs and other tissues.