Sentences with phrase «immune cells attacking»

When immune cells attack myelin, nerve cells can't send their signals.

It has been understood for several years that, in patients suffering from this disease, immune cells attack the aquaporin - 4 water channel of the brain cells.

Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft - versus - host disease (GVHD), a serious and potentially life - threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.

In EAE, as with MS, immune cells attack a nerve cell protein called myelin, causing symptoms ranging from impaired vision to severe motor dysfunction and even death.

This is a schematic of how a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient's own immune cells attack Dsg3, which normally adheres skin cells.

In multiple sclerosis, an individual's immune cells attack myelin, the protective sheath that covers axons — the brain's messengers.

Schematic of how a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient's own immune cells attack Dsg3, which normally adheres skin cells.

Not exact matches

The drug was a single infusion of a patient's own immune cells that have been modified reprogramed to attack their deadly cancer.

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

CAR - T cell therapy is a form of immunotherapy, a rapidly developing cancer treatment that uses patients» own immune cells to attack tumors.

Rather than an activator of T cells, the molecule acted like a brake, stopping the immune system from its attack.

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

Immune oncology drugs use a mechanism to enable the immune system to «uncloak» hidden cancer cells in the body and then attack them.

Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.

The drug has an unfortunate side effect of tricking the immune system into attacking healthy cells, but the relative damage was insignificant compared to what cancer would have done to them.

This is the group of genes which act as the immune system markers on cells, protecting them from being attacked by the system's anti-bodies.

This article is questionable as it has no links or actual references to the studies it talks about, like someone above has mentioned also there is no information on how the diagnosis were made, and lastly it does not take into account that celiac disease is NOT an allergy, it is an auto immune disease where the body attacks its own cells confusing them with gluten proteins, it is not about tolerance, I would not be trusting this information, do lots of research on your own from legitimate scientific sources before making a decision.

* CD4 cells are a component of the immune system attacked by HIV.

«These attacks have grown in magnitude and they include attacks on security services, we have incidents where military officers have been lynched by mobs, we have instances where these vigilante groups calling themselves variously; Invisible forces, Delta forces, etc. invade police stations, break into cells and release suspects because they claim the NPP members are immune to any form of arrest in other words, they are living above the law because they happen to be members of a party living in power», he said.

Simberg and colleagues also tried turning off the complement system — a facet of the immune system responsible for clearing microbes and damaged cells — thinking that this complement system might be attacking, transporting or otherwise accidentally pushing liposomes from blood to cells.

An immune response, triggered by foreign neural stem cells, could actually help attack tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using stem cells to attack tumors.

A group of the nation's leading cancer research scientists and their Cuban counterparts are exploring how to advance cancer therapy, diagnosis, and prevention, including the use of immunotherapy to harness the body's immune systems to attack and eliminate cancer cells.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

If we can boost the effectiveness of these immune cells we are likely to be able to contain this infection at the point of attack and stop the virus from spreading in the first place.

Previously, Derek Danahy of the University of Iowa and colleagues showed that sepsis disrupts the immune system by reducing the amount and function of memory T cells that circulate throughout the body, recognizing and attacking specific bacteria, viruses, or cancer cells.

Two groups had their immune systems altered to produce fewer macrophages, the white blood cells that attack pathogens.

We now know the virus attacks a person's T lymphocytes, a type of white blood cell that plays a central role in the immune system.

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

Hoxb8 is usually active in microglia, immune - system cells that clean up damaged neurons and attack pathogens in the brain.

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

Typically, when the body senses a foreign substance such as a virus or a bacterium, it sends immune cells to attack the invader while also bolstering the immune system as a whole.

It indicates to the immune system that a cell is «self,» and so not to be attacked.

«If we learn how to control dendritic cells, we could strengthen our immune response to infection when needed, or weaken the action of certain immune cells that attack the body's own tissues in autoimmune disease.»

When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop «T cell exhaustion,» becoming less effective and losing their ability to attack and destroy the invaders of the body.

But during pregnancy, the fetus is protected from the mother's immune system by the placenta, which has specialized cells — called trophoblasts — that can burrow into the mother's body without exciting an attack by the immune system.

Pembrolizumab, which is marketed under the brand name Keytruda, works by turning off the immune system's brakes, allowing its T cells to recognize and attack cancer cells.

These cells play a key role in autoimmune disease — in which the immune system mistakenly identifies the body's own tissues as foreign and attack them.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

They also found AXIN2 in the damaged nerve cells of adults with multiple sclerosis, a disease in which the immune system attacks myelin.

Normally, this protein prevents immune cells from attacking an patient's own body.

«The multiple sclerosis drugs currently on the market and being tested elsewhere seek to reduce the immune attack on cells, but none target neurodegeneration nor do they work to restore nerve cell function.

Bone marrow transplants are sometimes needed to treat immune diseases that attack these stem cells, or in certain types of anaemia, in which the body can't make enough blood cells or clotting factors.

Blood from people affected by the 2014 Zika outbreak in French Polynesia provides the first evidence that the virus can make the immune system attack nerve cells

Others are finding ways to boost the body's own immune system to attack cancer cells.

However, those antibodies also bind to leiomodin - 1, so the immune system - incorrectly - will attack brain cells that contain that protein, which can result in symptoms of Nodding syndrome.

CRH, in turn, triggered production of the cell surface protein FasL; trophoblasts expressing FasL then form a protective shield of sorts around the embryo by forcing any attacking immune cells to self - destruct.

When the body senses these particles, it kick - starts specialized immune defenses, including the production of immune cells known as lymphocytes, which learn to recognize and attack viral DNA.

There was another intriguing connection: Acinetobacter are molecular mimics of proteins found in myelin, the nerve cell coating that the immune system attacks in MS.. That suggests the bacteria might trigger immune attacks that hit myelin, too, as when soldiers who inadvertently resemble the enemy get hit by friendly fire.

Antibodies and T cells against the protein could cause the immune system to attack cells carrying it, making gene therapy ineffective.