In models lacking NLRX1, innate
immune cells called macrophages produce higher levels of IL - 6, a signaling molecule that has a central role in colorectal cancer development.
In previous research, a team led by the same Artyomov showed that inflammatory
immune cells called macrophages produce significant amounts of itaconate when they detect bacteria.
Not exact matches
In this study, the researchers found that a specific population of
immune cells called macrophages have the ability to secrete or
produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial
cells to promote wound healing.
Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly
produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive
immune cells called macrophages.
Moreover, the idea that the brain was isolated from
immune reactions was challenged long ago by insights about microglia
cells, a type of
macrophage which resides in the brain, engulfs antigens, and
produces pro-inflammatory signaling molecules
called cytokines.