Sentences with phrase «immune cells designed»

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The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.

The scientists hope understanding how immune cells adapt as they enter different tissues will spur the design of better, more specific, medicines.

Injections of killed stem cells, designed to help the immune system recognise cancers, have been found to protect mice from developing tumours

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.

The chips are designed to look for the activation of certain white blood cells, which would indicate the immune system was going to work to fight the infection.

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

Researchers have designed a nanoparticle - based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

But this information is vital for scientists who are trying to design vaccines to protect against sexual transmission because inside cells, the virus may go undetected by the immune system.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

In a new study published in Science Advances, a group of University of Wisconsin - Madison researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency, to shine a spotlight on the virus so the immune system knows to fight.

Daniel Getts, chief scientific officer of Cour Pharma in Chicago, Illinois, says he has written WHO to suggest the use of his company's Immune Modifying Nanoparticles, designed to reduce tissue damage by binding immune cells called monocytes.

«It is likely to be part of the mechanism for changing the functions of other immune cells, and the insight may help in designing vaccines.»

For example, he's designing nanoparticles that bait specific immune system cells by displaying certain features on their surface; inside, the nanoparticles contain an antigen of a particular microbe.

Just as cells of the immune system use antibodies to recognize pathogens, researchers in this study designed antibodies to recognize a protein over-expressed by these cancer cells, namely the protein mesothelin.

The immunotherapy is designed to activate the disease - fighting immune system to attack and kill tumor cells.

The sponge is implanted under the skin, and is designed to recruit and reprogram a patient's own immune cells «on site,» instructing them to travel through the body, home in on cancer cells, then kill them.

«The fact that the field has successfully bioengineered antibodies to oversee the removal of TNF - a suggests that we can design other antibodies to remove spleen - derived immune cell subsets, or the proteins issuing from failing hearts that turn them on,» Prabhu added.

Once activated, the circuit expresses proteins designed to direct the immune system to target the tumor cells, including surface T cell engagers, which direct T cells to kill the cells.

In the new study, researchers used specially designed antibodies in the mice to first wipe out rogue beta - cell - killing T cells from the immune system.

Hu14.18 K332A is a laboratory - produced antibody designed to activate the immune response against tumor cells by recognizing and binding to an antigen found on the surface of most neuroblastoma tumor cells.

ViaCyte's PEC - Encap ™ (also known as VC - 01) product candidate delivers the same cell therapy as PEC - Direct but uses a proprietary device called the Encaptra ® Cell Delivery System that is designed to protect the cells from the patient's immune syscell therapy as PEC - Direct but uses a proprietary device called the Encaptra ® Cell Delivery System that is designed to protect the cells from the patient's immune sysCell Delivery System that is designed to protect the cells from the patient's immune system.

Although, Hedrick and Linden target different cell types, innovations by both groups could encourage clinical tests of drugs designed to switch on a patient's immune cells by eradicating secondary lung malignancies.

Her aim is to understand, at the molecular level, the mechanisms that control communication between the brain, immune system, and blood vessels — with the ultimate goal of designing new therapies that slow, stop, or reverse the progression of a wide range of neurological disorders, such as MS. Recently, Dr. Akassoglou's lab identified how microglia — a type of immune cell that acts as the brain's first line of defense — are activated when fibrinogen enters the brain or spinal cord.

«Research focused on basic B cell biology is the foundation for the development of an HIV vaccine designed to drive the B cell arm of the immune response.»

Cancer vaccines are designed to stimulate an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.

The findings have implications for the design of cancer vaccines and what are called adoptive T cell therapies; when T cells are collected from a patient and grown in the laboratory, increasing in number before they are given back to the patient to help the immune system fight disease.

New treatments designed to direct the immune system against specific cancer cells — called immunotherapy — are also under study.

Our immune system is designed to recognise the cells that make up our bodies and repel any foreign invaders such as viruses.

The treatment is designed to stop the immune systems of those with type 1 diabetes, a condition which usually develops in childhood, from mistakenly destroying the cells which create insulin.

Our chemically modified siRNA molecules, designed to retain stability in the bloodstream without stimulating the immune system, are able to target certain kidney cells without the need for a delivery system when given intravenously.

One interesting strategy is the use of engineered immune cells which are designed to specifically target and destroy HIV.

Therapeutic vaccines are designed to elicit an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.

Monoclonal antibodies are molecules, generated in the lab, that are designed to target cancer cells and recruit immune cells to attack.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Immune Design is a clinical - stage biotechnology company made up of collaborative, «can do», experienced professionals passionate about leveraging the company's leading - edge technologies that target dendritic cells for a more precise immune response for the treatment of cancer and other chronic conditions.

«The promising results show that personalised cancer vaccines designed to treat skin cancer are safe to use, and that for some patients, they can successfully harness the power of the body's own immune system to kill cancer cells,» Pickworth added.

By blocking inhibitory molecules or, alternatively, activating stimulatory molecules, these treatments are designed to unleash or enhance pre-existing anti-cancer T cell immune responses.

Therapeutic cancer vaccines are designed to elicit an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.

Multiplexed Imaging Here the goal is to add spatial resolution to cytometry - data in order to understand, in a tissue, WHERE immune and cancer cells interact We design, develop and apply methods for multiplexed visualization of protein and RNA molecules in tissue sections.

Monoclonal antibodies are a special type of protein designed to target antigens, or markers, located on the surface of cancer cells; antibodies locate antigens and recruit immune cells to attack.

His work also suggests that therapies designed to block immune checkpoints, such as anti-PD-1 antibodies, may act in part by shifting this metabolic competition back in favor of immune cells.

NEW YORK, June 1, 2016 — Cancer immunotherapy, which is designed to empower a patient's own immune system to eliminate cancer cells anywhere in the body, has produced remissions in very advanced cancers, including former U.S. president Jimmy Carter in 2015.

«This loss - of - HLA mechanism suggests that, when designing vaccines and cell - based therapies, we need to target antigens that are presented to the immune system,» says Swanton.

Immune Design is a new generation vaccine company built on emerging understanding of the role of dendritic cells in determining an effective immune response.

The encapsulation device is designed to protect the cells from being destroyed by the immune system and allows the cell therapy to be removed and replaced as necessary.

A novel approach to cancer immunotherapy — strategies designed to induce the immune system to attack cancer cells — may provide a new and cost - effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma.

When implanted, PEC - 01 cells are expected to differentiate into pancreatic islet cells that produce insulin and other hormones that regulate blood sugar, while the Encaptra device is designed to protect the cells from immune destruction.

ZVex ® and GLAAS ™ are our complementary discovery platforms designed to activate and expand the immune system's natural ability to create tumor - specific cytotoxic T cells (CTLs) in vivo.