Sentences with phrase «immune cells in the lab»

Then the team used the cells from the surgery to grow billions of cancer - fighting immune cells in the lab.

Not exact matches

«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human cells.

This new kind of approach to fighting blood cancers is truly personalized; immune T - cells are extracted from patients, genetically tinkered to home in on an destroy cancerous cells, multiplied in a lab, and then jolted back into the patient's body within about two weeks.

In 2011, the team was the first to report functional, lab - grown anal sphincters bioengineered from human cells that were implanted in immune - suppressed rodentIn 2011, the team was the first to report functional, lab - grown anal sphincters bioengineered from human cells that were implanted in immune - suppressed rodentin immune - suppressed rodents.

«Our lab specializes in developing novel genetic methodologies to study T cell repertoires, but we had never applied this technology to study how the immune system responds to an infection,» says Emanual Maverakis, M.D., associate professor of dermatology at the University of California, Davis School of Medicine.

«When we analyzed tissue samples in the lab, we found that exposing white fat to macrophage cells from the immune system inhibited the transformation.»

One approach would be to identify immune cells in a tumour, grow them in a lab, and then infuse them back into the patient — a technique called adoptive cell transfer.

In 1963, the couple moved to NYU to work as immunology research fellows in the lab of Baruj Benacerraf (who shared the Nobel Prize in Physiology or Medicine in 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactionsIn 1963, the couple moved to NYU to work as immunology research fellows in the lab of Baruj Benacerraf (who shared the Nobel Prize in Physiology or Medicine in 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactionsin the lab of Baruj Benacerraf (who shared the Nobel Prize in Physiology or Medicine in 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactionsin Physiology or Medicine in 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactionsin 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactionsin the regulation of immune reactions).

In lab tests, the CpG - antigen package, at 300 nanometers in size, was absorbed 90 percent of the time by immune cells, the UI - led team reportIn lab tests, the CpG - antigen package, at 300 nanometers in size, was absorbed 90 percent of the time by immune cells, the UI - led team reportin size, was absorbed 90 percent of the time by immune cells, the UI - led team reports.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

To investigate the relationship between temperature and immune response, Iwasaki and an interdisciplinary team of Yale researchers spearheaded by Ellen Foxman, a postdoctoral fellow in Iwasaki's lab, examined the cells taken from the airways of mice.

«Ultimately, the virus is suppressing the immune system for its own benefit, and promoting the formation and proliferation of cancer cells may be just a side effect of that,» says Sharon Kuss - Duerkop, PhD, research instructor working in the lab of CU Cancer Center investigator Dohun Pyeon, PhD.

Previous studies in the lab showed that once HCMV is inside the cell, it quickly becomes latent by entering the cell's nucleus and co-opting a cellular protein called Daxx — part of the intrinsic immune system — to shut down its own replication, the process of reproducing its genetic material to make more copies of itself.

When they knocked two of these genes out of the bacterium's genome, it couldn't survive in a lab culture of immune cells, they report in the 26 May issue of Science.

Johannes Scheid, a student in Nussenzweig's lab, isolated it several years ago from an HIV - infected patient whose immune system had an exceptional ability to neutralize HIV in the blood by preventing the virus from infecting and destroying a specific type of immune cells, called CD4 cells, in patients.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

They tested 120 neural stem cell lines in the lab for stability and robustness and in animals for the capacity to engraft with minimal immune rejection.

A solution, Cheng and his colleagues thought, could be to grow blood cells in the lab that were matched to each patient's own genetic material and thus could evade the immune system.

An active area of investigation in our lab concerns the role of another cytokine produced mostly by innate immune cells, the IL - 12 family member IL - 27.

The project began when a post-doc in the Mullins lab, Lillian Fritz - Laylin, collected a time - series of images of macrophage - like immune cells in motion using Betzig's new microscope.

Rather than round up a patient's T cells and re-engineer them in a lab to find cancer, this treatment harvests a class of immune «helpers» called dendritic cells.

Now, a new STEM CELLS study from the labs of Qing - Ling Fu (Sun Yat - sen University, Guangzhou) and Zhongquan Qi (Xiamen University, Fujian, PR China) has described the effect of iPSC - MSCs on immune T cells in a relevant in vivo mouse mCELLS study from the labs of Qing - Ling Fu (Sun Yat - sen University, Guangzhou) and Zhongquan Qi (Xiamen University, Fujian, PR China) has described the effect of iPSC - MSCs on immune T cells in a relevant in vivo mouse mcells in a relevant in vivo mouse model.

Scientists from the Sundrud lab have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease as well as steroid resistance associated with the disease.

In CAR T therapy, a person's own T cells — disease - fighting immune cells — are removed and sent to a lab where they are genetically re-engineered to produce chimeric antigen receptors (CARs) on their surface.

With their deep expertise in the biology of senescent cells, the Campisi lab will be focused on fundamental research into questions like how senescent cells vary in their susceptibility and resistance to immune clearance (depending on factors like their tissues of residence or the pathway that led them into senescence); the targets and mechanisms used by NK cells to clear senescent cells; and why subsets of senescent cells might persist when their similarly - situated neighbors are cleared out (and what might allow us to overcome that resistance).

The lab is characterizing the quantity and quality (i.e. B and T cell) of the immune responses induced or generated by these DNA plasmids in order to improve their ability to mediate virus neutralization and clearance.

Although progress toward harnessing the immune system to attack tumors has been «enormous,» he said, his lab and many others are seeing in more and more studies — in lab mice as well as patients — that «immuno - oncology» will not be as simple as stimulating T cells to attack tumors.

Monoclonal antibodies are molecules, generated in the lab, that are designed to target cancer cells and recruit immune cells to attack.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

She joined Dr. Yu's and Dr. Lichterfeld's labs in August 2015 as a Postdoctoral Fellow to study specifically HIV reservoir (s) in different immune cell types using HIV nucleotide sequence diversity as markers.

Indeed, the lab found that small molecules enhancing Nurr1's function can robustly suppress neuroinflammation and expression of proinflammatory genes in immune cells.

The research team also created a synthetic version of the virus in a lab and found that toying with Tat completely outside of a host immune cell could also switch it on and off, building on a study published last year which concluded that latency was «hard - wired» into the virus.

Important reports from the Weiner lab include the first DNA vaccine studied for HIV as well as for cancer immune therapy of cutaneous T cell lymphoma, the early development of DNA encoded genetic adjuvants, including IL - 12, advances in gene optimization, and advances in electroporation technologies resulting in improved gene delivery.

However, in a 2014 study, Dr. Sulzer's lab demonstrated that dopamine neurons (those affected by Parkinson's disease) are vulnerable because they have proteins on the cell surface that help the immune system recognize foreign substances.

In addition to checkpoint blockade antibodies, the editors also pointed to recent advances in adoptive cell therapy — removing a patient's immune cells, engineering them in the lab, and then re-infusing them back into the patient to fight canceIn addition to checkpoint blockade antibodies, the editors also pointed to recent advances in adoptive cell therapy — removing a patient's immune cells, engineering them in the lab, and then re-infusing them back into the patient to fight cancein adoptive cell therapy — removing a patient's immune cells, engineering them in the lab, and then re-infusing them back into the patient to fight cancein the lab, and then re-infusing them back into the patient to fight cancer.

While the cancer normally excludes immune T - cells, the Evans lab discovered that modified vitamin D reprograms the cancer environment in a way that may allow the Merck drug Keytruda ® to invade and destroy the tumor.

The cell types involved in diabetes — the beta and immune cells — are being studied in the culture dish, as well as transplanted into lab animals.

His lab demonstrated that neoantigens (mutated proteins unique to cancerous cells) present in most or all cells within a tumor are much more likely to be effectively recognized by the immune system.