Sentences with phrase «immune checkpoint blockade»

«Cancers evade immunotherapy by «discarding the evidence» of tumor - specific mutations: Discovery could explain widespread acquired resistance among patients treated with immune checkpoint blockade drugs.»

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

A Brief Report published recently in the New England Journal of Medicine detailed two cases of patients treated with combination immune checkpoint blockade for metastatic melanoma who developed myositis, early progressive and refractory cardiac electrical instability, and myocarditis.

«These observations in mouse models of prostate cancer, using a sophisticated genetic approach developed by James Horner at MD Anderson, illuminate a clinical path hypothesis for combining immune checkpoint blockades with MDSC - targeted therapies in the treatment of this aggressive cancer.»

Myocarditis is a rare and sometimes lethal complication of combination immune checkpoint blockade for metastatic melanoma.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

Allison pioneered immune checkpoint blockade, an approach that treats the immune system, rather than the tumor directly, by blocking molecules on T cells that shut those attack cells down, protecting tumors from immune response.

ESR03, Marina Juraleviciute, and SWISS01, Sabrina Schindler, were both awarded Young Scientist Travel Awards for the 2017 Congress based on the scientific merit of their poster abstracts entitled: «Dissecting molecular and genetic determinants of UV response using iPSC based melanocyte models» and «The peripheral blood TCR repertoire might facilitate patient stratification for immune checkpoint blockade inhibition in metastatic melanoma» respectively.

«While immune checkpoint blockade therapy is effective in many cancers, it has been less successful for this particular form of prostate cancer, which has motivated a search for targeted therapies that overcome this resistance.»

The ultimate goal of Dr Janji's research team is to provide the proof of concept that targeting autophagy could improve the efficacy of current immunotherapies, notably those based on immune checkpoint blockades.

Among the 93 patients treated with anti-PD1 immune checkpoint blockade, the researchers had gut microbiome samples from 30 responders and 13 non-responders.

They found that PD - L1 immune checkpoint blockade significantly improved the therapeutic efficacy of stem cell based oncolytic virotherapy in melanoma brain metastasis.

The other involves what are known as «immune checkpoint blockade inhibitors,» which Parker describes as «retraining» the «troops» to be able to get around cancer's defenses.

The lab developed this vaccine and is currently working to improve the efficacy of the vaccine using combination therapies with immune checkpoint blockade antibodies in mouse models.

Increases in immune cell infiltrates were observed in 4/4 patients in whom single - or double - line immune checkpoint blockade had failed.

This proliferation of scientific knowledge has led to multiple potential new treatments including new immune checkpoint blockade therapies, novel T - cell approaches, agents targeting monocytes and macrophages, as well as new approaches inhibiting immune receptors and cytokine signaling.

For their collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.

The U-M team used immune checkpoint blockade combined with gene therapy to block the cancer cells from hijacking the host immune system.

Checkpoint blockade: Fewer but stronger results Allison pioneered immune checkpoint blockade, an approach that treats the immune system, rather than the tumor directly, by blocking molecules on T cells that shut those attack cells down, protecting tumors from immune response.

Whilst there Sabrina presented a poster showing her research work entitled: «The peripheral blood TCR repertoire might facilitate patient stratification for immune checkpoint blockade inhibition in metastatic melanoma.»

«We hope the implementation of our gene therapy strategy for gliomas, used in combination with immune checkpoint blockade, will eventually provide successful treatment for patients with this devastating brain cancer,» says Maria Castro, Ph.D., co-senior author and U-M professor of neurosurgery and cell and developmental biology.

Advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune - busting cells commonly associated with poor patient prognosis and therapy resistance.

However, immune checkpoint blockade therapies [such as pembrolizumab and nivolumab] can stop this from happening, so we suggest that immune checkpoint blockade might be a suitable form of immunotherapy to give to ovarian cancer patients after chemotherapy,» she added.

One phase I trial of an immune checkpoint blockade drug combined with two established targeted therapies yielded 40 - 50 percent response rates among patients with metastatic kidney cancer.

Castro and Lowenstein's team combined the immune checkpoint blockade approach with gene therapy.

Researchers found the gene therapy approach had stronger results when used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.

The two groups converged on a discovery that resistance to immune checkpoint blockade is critically controlled by changes in a group of proteins that regulate how DNA is packaged in cells.

The immune checkpoint blockade drug nivolumab reduced tumor burden in 24.4 percent of patients with metastatic bladder cancer, regardless of whether their tumors had a biomarker related to the drug's target, according to clinical trial results from The University of Texas MD Anderson Cancer Center.

We also apply these techniques to model systems in order to identify subgroups of patients who are uniquely sensitive or resistant to targeted therapies, such as poly (ADP - ribose) polymerase (PARP) inhibitors or immune checkpoint blockade.

For this purpose, a third trial, also led by Dr. Amaria, teams adaptive T - cell therapy (a process where native immune system cells are collected from the patient's tumor, multiplied in the laboratory up to 150 billion cells, and then re-infused to the patient) with an immune checkpoint blockade.

In honor of James Allison, Lieping Chen, Gordon Freeman, Tasuku Honjo and Arlene Sharpe for contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.