Sentences with phrase «immune checkpoint inhibitor therapy»

Additionally, the greater the number of these trunk neoantigens, the more likely the patient will respond to immune checkpoint inhibitor therapy, an antibody - based intervention that unleashes T cells to attack tumors.

«We predict that immune checkpoint inhibitor therapy will be more effective for HPV - active tumors than HPV - inactive tumors.

«HPV - active tumors have high expression of immunoregulatory genes and therefore may respond to immune checkpoint inhibitor therapy.

Not exact matches

It would involve gene therapy delivered at the time of surgery and systemic delivery of the immune checkpoint inhibitors, such as through IV injection.

The novel drug combination allows the rapidly emerging cancer therapies called immune checkpoint inhibitors to be incorporated into a transplant patient's cancer treatment regimen.

We also apply these techniques to model systems in order to identify subgroups of patients who are uniquely sensitive or resistant to targeted therapies, such as poly (ADP - ribose) polymerase (PARP) inhibitors or immune checkpoint blockade.

«The data presented at AACR provide important new models and mechanistic insights that inform our planned development efforts to evaluate the ability of microbiome therapy to augment immune checkpoint inhibitors,» said David Cook, Ph.D., Chief Scientific Officer and Executive Vice President of Research at Seres.

The data presented provide new insights on the potential mechanism by which Seres» microbiome therapies could improve the outcomes of cancer patients treated with immune checkpoint inhibitors.

Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and technologies with high therapeutic potential.

The researchers hypothesized that antibiotics might even have an effect 60 days from start of therapy with immune checkpoint inhibitors.

These treatments can be broken into four categories: monoclonal antibodies, checkpoint inhibitors and immune modulators, cancer vaccines, and adoptive cell therapy.

The success of immune checkpoint inhibitors in cancer therapy continues to grow, but a complete understanding of their underlying mechanisms is still lacking.

The study highlights an opportunity to combine this form of therapy with cancer immunotherapy drugs such as checkpoint inhibitors, which unleash the immune system's full cancer - fighting power, the researchers say.

The first three drugs are checkpoint inhibitors that «take the brakes off» the immune system and enable it to fight cancer; the last is an oncolytic virus therapy that stimulates stronger anti-tumor immune responses.

Current immunotherapies for colorectal cancer fall into seven broad categories: checkpoint inhibitors and immune modulators, monoclonal antibodies, therapeutic vaccines, adoptive cell therapy, oncolytic virus therapy, adjuvant immunotherapies, and cytokines.

They fall into six broad categories: checkpoint inhibitors and immune modulators, cancer vaccines, adoptive cell therapy, monoclonal antibodies, cytokines, and adjuvant immunotherapies.