Sentences with phrase «immune checkpoint pathway»

PD - 1, which stands for programmed cell death 1, is the second immune checkpoint pathway currently being targeted with immunotherapies.

How much checkpoint inhibitor immunotherapy can benefit these patients is unknown, and Dr. Kim's work seeks to define the immune checkpoint pathways in FL - HCC.

Not exact matches

In healthy individuals, these immune checkpoints prevent autoimmunity, but many cancers exploit the same pathways to shield themselves from an immune attack.

Commenting on the two studies, Baas says that finding a good treatment for mesothelioma has been a challenge for many years and has so far led to many disappointments, so there is a need for investigation into new pathways such as the use of immune checkpoint inhibitors that target the PD - 1 / PD - L1 pathway.

AMD3100, alone or in combination with VIC - 008, decreases expression of the immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway modulates PD - 1 expression.

Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD - 1 / PD - L1 pathway.

The immune checkpoint refers to a range of immunoregulatory pathways that enhance or moderate immune responses.

One strategic avenue that Sharma and her colleagues are exploring to enhance checkpoint immunotherapy's effectiveness in more tumor types involves targeting other immune - related pathways in combination with existing immunotherapies.

Do you think if I tried to explain what immunotherapy is by mentioning signalling pathways, immune checkpoints or cytokines, my message would be effectively transmitted?