Current topics include vaccine efficacy testing and
immune correlates of TB, AMA1 as a malaria blood stage vaccine candidate in clinical development and development of new drugs active against malaria hypnozoites.
They have been actively involved in finding
immune correlates of protection, implementation of new TB vaccines and testing of vaccine candidates in murine models.
Recent publication: T - cell activation is
an immune correlate of risk in BCG vaccinated infants Nature Communications 7, Article number: 11290 (2016) doi: 10.1038 / ncomms11290 Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O'Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington - Kandt, Zita - Rose Manjaly - Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn - Nicholson et al..
Not exact matches
Asthma has been
correlated with an overabundance
of one type
of immune cell called M2 macrophages in the lungs.
This program, resulting in shorter 3 ′ UTRs, is a characteristic
of gene expression during
immune cell activation and
correlates with proliferation across diverse cell types and tissues.
By combining multiple images, the researchers produced movies
correlating the production
of hydrogen peroxide to the activities
of the
immune system cells.
Analyses
of RV144 volunteers revealed that particular vaccine - induced
immune responses, including production
of certain antiviral antibodies and CD4 + T cell responses to HIV's outer shell, or envelope,
correlate with reduced HIV infection.
Their study
of fecal samples from 105 patients treated with
immune checkpoint blockade indicates that certain characteristics
of patients» microbiomes
correlate with slower disease progression while other qualities are associated with rapid worsening
of the disease.
The Johns Hopkins team tested ImmunoMap's ability to
correlate immune responses on receptor sequencing data from T - cells in the tumors
of 34 patients with cancer enrolled in a nationwide clinical trial
of the immunotherapy drug nivolumab.
But if the virus triggers a prolonged
immune amnesia, the number
of deaths in a particular year might
correlate to the total number
of cases in that year and the previous year or two.
Kim et al. suggest that moving away from empirical research to either systems analysis or hypothesis driven approaches may advance our vaccinology understanding.5 Interrogation
of peripheral blood responses following vaccination, termed «systems vaccinology», has led to the identification
of immune signatures and pathways that are
correlated to
immune responses.
If sufficient 1,25 - dihydroxyvitamin D is produced, it may exert paracrine effects on surrounding T lymphocytes, thereby regulating the tissue - specific
immune responses.10 Some support for this hypothesis comes from recent experiments showing that mice fed diets high in vitamin D had significantly fewer clinical and pathological signs
of EAE than mice fed a vitamin D — deficient diet.37 Central nervous system levels
of 1,25 - dihydroxyvitamin D, but not blood levels, were higher in supplemented mice than in vitamin D — deficient mice and
correlated inversely with disease severity.
The team analyzed the frequency
of different types
of immune cells in blood collected from 110 one year - old study participants, the presence
of immune - stimulatory components in the subjects» house dust and asked whether any
of the factors
correlated with an increased
of asthma at age seven.
In this program, an array
of patient - derived isolates will be studied in mice, and parallel evaluation
of immune cell dynamics and cytokine profiles will inform about potential
correlates of disease or protection.
The workshop will include research on stem cells and aging, implications
of aging on
immune function (immunosenescence,
immune reconstitution), thrombosis and aging, and
correlates of frailty in hematology.
Circulating levels
of... a marker
of intestinal epithelial cell damage, were significantly elevated in the affected individuals and
correlated with the
immune responses to microbial products...
Do any mushroom extract supplements such as beta — 1,3 / 1,6 - d - glucans or AHCC (Active Hexose
Correlated Compound) have credible evidence
of efficacy in strengthening the
immune system?
Active Hexose
Correlated Compound (AHCC), a hybrid
of several mushrooms, is the top - selling
immune - enhancing supplement in Japan.
Likewise, if roughly 80 percent
of the
immune system is located in the gut, and stress weakens the
immune system, gut health and stress are directly
correlated.
«Researchers have observed that low levels
of glutathione are directly
correlated with nearly all degenerative and chronic diseases, including cancer, cystic fibrosis, cardiovascular disease,
immune dysfunctions, neurodegenerative diseases & more.»
According to a study published in 2008, repression
of the HGH / IGF -1 / insulin axis is
correlated with an increased percentage
of total body and visceral fat, along with decreased muscle mass, decreased physical fitness and decreased
immune function.
This phenomenon
of dog ear problems is
correlated with a dog having a depressed
immune system and problematic environment in the ear.
Having a positive attitude seems to
correlate with an increased ability
of the
immune system in fighting diseases.