Sentences with phrase «immune cytotoxicity»
They found that decreased presence of lymphatic vessels and reduced immune cytotoxicity were more strongly associated with the metastatic process than tumor - intrinsic factors such as chromosomal instability or cancer - associated mutations.
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The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].
Intracellular retention of the NKG2D ligand MHC class I chain - related gene A in human melanomas confers immune privilege and prevents NK cell - mediated cytotoxicity.
Trastuzumab directly inhibits the proliferation of HER2 - overexpressing breast cancer cells and induces immune - mediated killing of target cancer cells through antibody - dependent cellular cytotoxicity [20].
The systemic effects of stress include increased levels of stress hormones such as cortisol, a decline in certain aspects of immune system function such as natural killer cell cytotoxicity or secretory - IgA levels, and a disruption of gastrointestinal microflora balance.
For example, studies of medical students facing examinations and kindergarten children beginning school reveal changes in immune functioning potentially prognostic for adverse health outcomes, including changes in numbers of total t - lymphocytes, natural killer cell cytotoxicity, and lymphocyte responsivity to mitogenic stimulation (e.g., 8, 9).