Sentences with phrase «immune disease mechanisms»
Dr. Alan S. Cross, Professor of Medicine at University of Maryland School of Medicine, who was not involved in the research, shared his input: «This is a major conceptual breakthrough in our understanding of infection and immune disease mechanisms and may have implications for novel approaches to the treatment of other diseases characterized by cytokine storm.
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Another study found that maltodextrin impairs cellular antibacterial responses and suppresses intestinal antimicrobial defense mechanisms, leading to inflammatory bowel disease and other GI conditions that arise from an inappropriate immune response to bacteria.
The three main conditions — celiac disease, gluten sensitivity, wheat allergy — are based on very different mechanisms in the immune system.
The work was on the role of interleukin - 1 in the pathology of graft - versus - host disease (GVHD), the mechanism by which the new immune system, which a patient receives as a bone marrow transplant, attacks the patient's body following the transplantation.
Scientist at the University of Copenhagen and Skejby Hospital will continue their work on how bacteria might affect the balance between the immune defence mechanism and the disease.
Professor Nutt said increasing our knowledge of the mechanisms that controlled the immune response was vital for understanding how immune and inflammatory diseases arise and, ultimately, developing more effective treatments.
«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.
«Like zebrafish, we have this rich source of gut microbes that have figured out how to coexist with us and soothe the immune system,» she says, adding that «there is enormous potential to harness those mechanisms» to address ailments such as inflammatory bowel disease and other chronic inflammation.
«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.
Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.
Once they found that the OTULIN gene was abnormal in the sick children, they studied the immune pathway in order to understand the mechanisms of disease and to improve treatment of these patients.
Unraveling how the immune and nervous systems interact has helped advance our understanding of many mechanisms within the brain, from development to diseases.
Dr. Ernst says that if such an antigen transfer system works to boost the immune response in TB, then a similar bypass mechanism could also be at work in other infectious diseases in which the invading microorganism has developed means to evade the immune system.
«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.
The specifics and mechanism remain unclear, but previous research has suggested that these early maternal immune compounds may have «educational effects» on the newborn's developing immune profile — that they may somehow be priming the system to be on the lookout for common local diseases or parasites.
Causes of the disease are poorly understood, although immune - mediated mechanisms are likely.
«More studies are required in order to make these important associations in terms of the effects of supplementation on cardiometabolic syndrome, the immune and inflammatory mechanisms of cardiovascular disease in postmenopausal women, and their quality of life,» Nahas said.
One possible mechanism mediating this preference is altered testosterone levels; men raised in environments with frequent diseases and germ exposure tend to have lower testosterone levels through adulthood, because testosterone can handicap immune function.
«Knowing this mechanism that underlies IL - 37's effect on the immune system now allows us to study IL - 37 function and perhaps dysfunction in a wide range of diseases,» says Mayumi Fujita, MD, PhD, investigator at the University of Colorado Cancer Center, associate professor in the CU School of Medicine Department of Dermatology, and the paper's senior author.
«Mechanism, possible treatment, for immune suppression in liver disease uncovered.»
Disease - causing pathogens have been shown to manipulate or attack the ubiquitination process to disarm immune cells and evade the body's defense mechanisms, he said.
As this regulation mechanism mediated by the immune system also plays an important role in other diseases such as leukemia, these findings could lead to novel therapeutic approaches.
The mechanism which underlies the susceptibility of liver disease patients to life - threatening infection has been uncovered by Wellcome Trust - funded medical scientists, who have also suggested a possible treatment to reverse immune suppression in these patients.
Leprosy hijacks our immune system, turning an important repair mechanism into one that causes potentially irreparable damage to our nerve cells, according to new research that uses zebrafish to study the disease.
Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.
«The grant provides us an exciting opportunity to understand these mechanisms in human cardiovascular disease and to discover new immune - based targets for cardiovascular disease,» says Hedrick.
The discoveries of the three Nobel laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms.
She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.
As a part of investigating the mechanism of disease, HIV infection impact on immune function, testing concepts for future study as HIV cure strategies, and immune recovery after ART, researchers at the Wistar Institute, in association with Philadelphia FIGHT and the University of Pennsylvania, are collecting peripheral blood in order to establish a repository of persons living with HIV that can donate blood.
(A) Cellular and molecular mechanisms of immune cell recruitment and activation in inflammatory and metabolic disease.
The first of its kind, the study provided specific markers to distinguish different disease states in asthma and paved the way for investigating the role of epigenetic mechanisms in other immune - mediated disorders and infectious diseases.
Properly engineered immune cells could enable scientists to direct highly specific, long - lasting immune response mechanisms against a disease.
College Park, MD (Scicasts)-- Researcher has uncovered a mechanism by which the bacteria that causes Lyme disease persists in the body and fights your early, innate immune responses.
Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...
«The observed increase in the ratio of cytotoxic CD4 T cells to CD4 helper T cells indicates that they are an important component of the protective immune response to viral infections and that their induction should be an important marker for successful vaccinations against certain viral diseases,» says postdoctoral researcher and first author Veena Patil, Ph.D. «But we really didn't know enough about their molecular profile and the mechanisms that drive their differentiation and maintenance.»
The new mechanism of cooperation reported might be implicated in protection against asthma, allergies and immune - mediated diseases that has been associated with a carrier state,» said Raquel Hontecillas, associate professor of immunology, NIMML co-director, and corresponding author of the publication.
«Discovering this mechanism of cooperation between H. pylori and its host has profound implications for the development of personalized treatments for infectious and immune - mediated diseases.»
Prior to joining Helmsley, Garabet was an assistant professor in the Immunology Institute at the Icahn School of Medicine at Mount Sinai where he led a research team investigating the implication of innate immune mechanisms in IBD, Crohn's disease, colorectal cancer, and other gastrointestinal disorders.
In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.
Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.
The group focuses on endogenous mechanisms that control (i.e. limit) immune responses in vivo and thereby prevent inflammatory disease caused by immune - mediated damage to host tissues.
Collectively, their work has elucidated foundational mechanisms in cancer's ability to evade immune recognition and, in doing so, has profoundly altered the understanding of disease development and treatment.
Little research has been performed to understand the specific rules and mechanisms of minimal residual disease, including clonal evolution at the metastatic site, epigenetic programs, interaction with organ defense and immune systems, mechanisms of dormancy and re-awakening, and last but not least, mechanisms of therapy resistance in specific niches.
The immune system can even start to attack itself — the hallmark mechanism of autoimmune diseases such as arthritis and chronic fatigue syndrome.
- Conclusion: The anti-gliadin (gluten) immune response in autism involves a mechanism that is different from celiac disease.
Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral tolerance to arrest autoimmune responses (31).
The researchers concluded, «A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease.
Endothelial cell activation, vascular smooth muscle dysfunction, oxidative stress, and inflammation, mechanisms which underlie heart disease, diabetes, and hypertension, are all variables which can precipitate or perpetuate immune imbalances in autoimmune disease.
A different immune mechanism, the innate immune response, comes into play in reactions of gluten sensitivity, as opposed to the long - term adaptive immune response that arises in celiac disease.
«Probiotics could theoretically even worsen a disease state, since it is possible that physiologic immune responses against benign commensals could fuel autoimmune responses via cross-reactivity (as we hypothesize) or other mechanisms,» he said.