One week ago she was diagnosed with Uveitis for the second time and now there are concerns of another auto
immune disease surfacing.
Not exact matches
«By tuning the
surface properties and pore size of the MSRs, and therefore controlling the introduction and release of various proteins and drugs, we can manipulate the
immune system to treat multiple
diseases.»
King explained that the
immune system responds to repetitive, symmetric patterns, such as those on the
surface of a virus or
disease bacteria.
Microbes that cause
diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell
surface receptors such as CTLA4 and PD - 1 — to slow
immune cells and prevent their elimination by the host.
Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell
surface proteins that function in the interactions of
immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune
disease.
Breaches in these layers, which can be caused by physical trauma or some sexually transmitted
diseases, allow HIV to bypass the protective
surface to access
immune cells that can be infected by HIV.
In CAR T therapy, a person's own T cells —
disease - fighting
immune cells — are removed and sent to a lab where they are genetically re-engineered to produce chimeric antigen receptors (CARs) on their
surface.
The awards span the broad mission of the NIH and include groundbreaking research, such as engineering
immune cells producing drugs at the site of
diseased tissue; developing a sensor to rapidly detect antibiotic resistance of a bacterial infection; understanding how certain parasites evade host detection by continually changing their
surface proteins; and developing implants that run off the electricity generated from the motion of a beating the heart.
However, in a 2014 study, Dr. Sulzer's lab demonstrated that dopamine neurons (those affected by Parkinson's
disease) are vulnerable because they have proteins on the cell
surface that help the
immune system recognize foreign substances.
For example, over 60 neuro - transmitters and hormonal receptors have been found on the
surface of our
disease - fighting
immune cells.