Sentences with phrase «immune escape»
Background: Expression of programmed death ligand (PD - L1 / B7 - H1 / CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells.
jcancer.org
Chris Plowe at the University of Maryland in Baltimore, who works on AMA - 1 vaccines, says agencies that fund vaccine trials do not test for effects on pathogens beyond monitoring for immune escape.
«This is the first study to illustrate that a structural abnormality in the 3» untranslated region of the PD - L1 gene causes an abnormally high production of PD - L1 protein, consequently aiding cancer immune escape,» says one of the lead authors, Keisuke Kataoka, at Kyoto University.
In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.
«Thus, if an HIV vaccine, antiretroviral therapy, or natural immune escape leads to weaker circulation viruses throughout the human population, the overall rate of transmission would likely be reduced.»
The parasites» AMA - 1 could change so that vaccine - induced immunity won't recognise it, a process called immune escape.
The central theme of the Shanker laboratory is to understand the molecular basis of functional crosstalk between the innate and adaptive lymphocytes, with a particular focus on preventing immune escape of solid tumors.
Some tumors exploit FasL [CD95L] expression to facilitate immune escape 203, 204, 205.
Colocalization of inflammatory response with B7 - h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
The combination was well tolerated and may address some of the immune escape mechanisms that limit the activity of current checkpoint blockade therapies.»
The real eye - opener, says Read, was that there was no immune escape: parasite AMA - 1 was unchanged (PLoS Biology, DOI: 10.1371 / journal.pbio.1001368).