Sentences with phrase «immune escape in»

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

Not exact matches

The child, nearly 4, was found to have high levels of HIV in her blood, suggesting that the virus had escaped from immune control.

«We hypothesized that individual mutations in viral genes could be expected to have a range of effects on the virus's ability to replicate, to infect new cells and escape the immune system,» Carlson says.

In escaping the immune system, the new mutations can inadvertently disrupt this golden binding point, which can be remedied by adding a sugar molecules in the just the part of the hemagglutiniIn escaping the immune system, the new mutations can inadvertently disrupt this golden binding point, which can be remedied by adding a sugar molecules in the just the part of the hemagglutiniin the just the part of the hemagglutinin.

«This confirmed our theory that both pathogenic and commensal bacteria can only survive in a host organism if they can escape or evade the immune system,» says Götz.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Publishing in Nature, the study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

«This is the first study to illustrate that a structural abnormality in the 3» untranslated region of the PD - L1 gene causes an abnormally high production of PD - L1 protein, consequently aiding cancer immune escape,» says one of the lead authors, Keisuke Kataoka, at Kyoto University.

Publishing in Nature, a recent study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Researchers at Albert Einstein College of Medicine in New York City wondered if having a gD - 2 component in a vaccine might «mask» other viral particles and allow them to escape immune detection.

Not surprisingly, repetitive exposure to the antibodies caused many mutations in the head, as it worked to escape the immune system's clutches.

A team of scientists from Singapore has discovered new ways in which cancers can escape the body's immune system.

Viruses that escape this checkpoint drain through lymph vessels to local lymph nodes, where it was assumed macrophages finished the job of the innate immune system before specialized adaptive immunity kicked in.

A study published by Cell Press November 21st in the journal Immunity reveals how HIV - 1 escapes detection by essentially becoming invisible to a patient's immune system, whereas HIV - 2 triggers protective immune responses in patients.

Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD - L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD - L1 blockade.

Thus, in a single experiment, the authors demonstrated that (1) CD4 + and CD8 + T - cells were the mediators of immune system rejection of transplanted tumor cells, and (2) d42m1 escape tumors develop from T - cell - dependent selection favoring cells without the spectrin - B2 antigen.

In fact, some researchers are even suggesting that lung cancers use the PD - 1 pathway to escape immune destruction in the first placIn fact, some researchers are even suggesting that lung cancers use the PD - 1 pathway to escape immune destruction in the first placin the first place.

What this suggests is that lung cancers are able to take hold in the lungs by disarming T cells and escaping the immune system's control.

April 17, 2018 - In our efforts to better understand how HIV escapes the effects of the immune system, scientists have discovered a new mechanism that could hold the answer.

This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).

Some of these randomly generated «escape mutants,» as they are called, would then be selected for survival in succeeding generations of the virus, since they would possess the advantage of being «fitter» — avoiding the body's immune response — than their nonmutated counterparts.

CRI postdoctoral fellow Dr. Haihui Lu at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, is studying some of the unique characteristics that differentiate metastatic cancer cells from primary tumor cells, and specifically aims to understand how these unique characteristics enable breast cancer cells to escape elimination by the immune system.

In this Review, we discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus controIn this Review, we discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus controin understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus control.

There's no doubt that probiotic exposure very early in life — primarily from a vaginal birth and exclusive breastfeeding for the first six months — helps to seal the «open guts» of babies, thereby preventing foreign substances like food particles from escaping through the intestinal wall into the bloodstream and stimulating allergic immune reactions that can last a lifetime.

In a recent mouse study, daily fasting flipped a genetic switch that strengthened the gut barrier against harmful bacteria, preventing the bad guys from escaping into the bloodstream to trigger an immune and inflammatory response.

Based on this data, researchers concluded that learned helplessness in rats who couldn't escape the shocks must have suppressed the immune response known to fight off cancer cells in tumors of this sort.

Probiotics may help to prevent this by closing the «tight junctions,» the spaces between cells in the small intestines so that these proteins can't escape and cause the immune system to overreact.

But in my case, the babesia symptoms did not show themselves until the lyme, several years post-bite, escaped control of my immune system.

Though not a terribly artful filmmaker, Robertson is good with actors in close - up (even if it is overused) and at allowing his patiently agitating camera to show the grit of dead - end poverty that the brother's gang world represents and Gen needs to escape: a pit of self - destruction populated by bleary - eyed toughs eager to brutalize and immune to hope.

Her world is upended when a scientist (Chiwetel Ejiofor) stumbles her way, having escaped the horrors beyond Ann's protected existence in a valley somehow immune to radiation.

The key ingredients being chicken and brown rice, this food is not only rich in protein but, is a rich source for vitamins and food - fiber Vets recommend this food as it boosts the immune health of the dogs that enable them to escape the threats of the outburst of various ailments.

Research suggests, if the dogs are served with good high protein dog food, regularly and in adequate volumes, the dog will be in the finest state of health that will ensure the solace and well being of the animal, boosting their immune systems that will enable the dogs to escape the attacks of various ailments.

Like the bacteria that cause gonorrhea, members of T. pallidum have multiple copies of the gene coding for the proteins that allow them to adhere to human cells — perhaps, as in the case of gonorrhea, these genes allow T. pallidum to alter their surface proteins in order to escape recognition by the immune system.