Sentences with phrase «immune evasion»

"Immune evasion" refers to the ability of certain organisms or cells to avoid or escape the normal defensive response of the immune system. It means that they can hide or trick the immune system so it cannot effectively recognize and eliminate them. Full definition
Publication: Plasticity in early immune evasion strategies of a bacterial pathogen.
I decided to write about the concept of immune evasion in cancer and one of the most currently used types of treatment in melanoma: immunotherapy.
We recently uncovered the important role played by myeloid - derived suppressor cells (MDSCs) to mediate tumor immune evasion in aggressive PCa.
A large proportion of its activities is devoted to malaria research with special emphasis on immune - regulation, immune evasion mechanisms, and genetics.
Mutations to these genes also represent a primary source for immune evasion (because they are the dominant proteins exposed on the viral surface) and why we need a new flu shot every year (i.e. because the dominant circulating strains are different from what our immune system has seen before).
The successful candidate will study how defined immune evasion functions encoded by CMV impact on immunological control of virus, and the progression of disease.
In summary, we report evidence for a β - catenin — mediated immune evasion in 42 % of melanoma primaries overall and in 73 % of those with the worst outcome.
MDSCs are a family of immune cells that are known to support immune evasion in a variety of ways.
The number of immune activating proteins destroyed by these virus genes was unprecedented given any previous discoveries of virus immune evasion strategies.
Thus, it is important to understand the nature of these tumor - specific immune evasion strategies.
This made it an important immune evasion strategy to overcome with a T - cell therapeutic approach.
The known mechanism whereby OspC facilitates primary infection through fostering immune evasion [53] should not be relevant when inoculating the spirochetes into SCID mice, yet the inoculation of ospC -LRB--) mutants into SCID mice has been unsuccessful [54].
Trypanosoma brucei metabolite indolepyruvate decreases HIF - 1α and glycolysis in macrophages as a mechanism of innate immune evasion.
Together with his group he has identified general immune evasion strategies which are shared by pathogenic microbes, including the human pathogenic yeast Candida albicans and Aspergillus fumigatus, as well as other pathogens, such as Gram negative and Gram positive bacteria.
To address the possibility that OspC is required for immune evasion, we inoculated severe combined immunodeficient (SCID) mice in parallel with WT, ospC mutant, and complemented clones (Table 4, which is published as supporting information on the PNAS web site).
Therefore, mutation (s) in alternate reading frame protein dysregulate p53 function and play a role in tumor immune evasion.
Through such an understanding it will be possible to block the tumor's immune evasion strategy which in turn will result in the cancer patient responding more effectively to an anti-cancer immunotherapy.
Tumor - associated B7 - H1 promotes T - cell apoptosis: a potential mechanism of immune evasion.
Research Interests: tumor immunology; suppressor cells; immune evasion; oncogenes; chemotherapy resistance
The PCa tumor microenvironment is comprised of a complex mixture of epithelial and stroma cell types engaged in multifaceted heterotypic interactions functioning to maintain tumor growth and immune evasion.
The JCVI GCID aims to study pathogens and the genetic determinants of their virulence, drug - resistance, immune evasion and interactions with the host, and host microbiome to advance research in pathogenicity, drug - resistance, disease transmission and vaccine development.
These tolerogenic effectors, while constitutively active in autoimmunity prevention, may play a pivotal role in maternal - fetal non-rejection, as well as in immune evasion of tumors and metastases.
Likewise, TGF - β production has been reported from a number of tumors, contributing to immune evasion.
The SPD genes, some of them known to mediate host - cell attachment, modification of host immunity and immune evasion, frequently presented copy number variations across strains or were found amplified in tandems forming gene arrays.
The researchers write that expression of DNRII also may be useful for other tumors that exploit this immune evasion mechanism, including melanoma and lung cancer.
To optimize the patient response to cancer vaccination requires studying immune checkpoints like CTLA - 4 and the mechanisms of tumor immune evasion.
[13] Another mechanism of immune evasion is tumor expression of programmed death ligand 1 (PD - L1)(also known as B7 - H1 or CD274) on many cancer types including RCC.
Extending those findings, Gack and her collaborators are now investigating the physiological role of this immune evasion strategy for other mosquito - borne viruses.
His thesis work with Dr. Chris Wilson was focused on the immune evasion strategies employed by herpes simplex virus.
Queen's University Belfast are seeking candidates whose research focuses on innovative molecular approaches to investigate viral mechanisms of immune evasion and alteration of cell signalling.
«I am thrilled to have made a difference in the lives of cancer patients and to be recognized by fellow scientists for my part in the discovery of the PD - 1 / PD - L1 and PD - L2 pathway and its role in tumor immune evasion.
They are seeking candidates whose research focuses on innovative molecular approaches to investigate viral mechanisms of immune evasion and alteration of cell signalling.
Analyse the data to learn about parasite population structure, epidemiology and history, mutational and recombinational processes generating diversity, evolutionary processes including drug resistance and immune evasion, and how such phenomena differ between populations and regions
The lab of Georgios Skiniotis, also at the LSI, used electron microscopy to show how NS1 associates with membranes of the infected cell, which the researchers suspected would be associated with both virus replication and immune evasion.
As current therapeutics are limited, it is essential to define the immune evasion strategies of these fungal pathogens which cause life - threatening infections and at the same time to understand the immune response of the human host to these fungal pathogens.
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