Sentences with phrase «immune killer cells»

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

Not exact matches

Studies show spending time among trees boosts the number of «killer cells» in the immune system that are key to beating infections and fighting cancer.

Basically, CAR - T therapy involves taking a patient's own immune «killer» T - cells, inserting new genetic code into those cells which turn them into cancer - hunters that can home in on malignant B - cells (another kind of immune cell), and then pumping these specialized leukemia - busting cells back into the patient.

Speaking of Novartis — the company's experimental CTL019, which is expected to be the first approved drug in a revolutionary new cancer treatment space that turns the body's own immune cells into cancer - killers, is already facing some apprehension from doctors and patient groups who are worried about its eventual pricing.

In clinical trials the treatment — which involves extracting individual patients» immune T - cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive lymphoma, and then pumping those modified killer cells back into the body — has shown major promise, in some cases eliminating all signs of the cancer in patients six months after treatment.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Swiss pharmaceutical giant Novartis has made waves with a drug pipeline that includes one of the most talked - about experimental cancer therapies in recent years — a treatment called Kymriah that reconfigures the body's own immune cells to become aggressive blood - cancer killers.

giant Novartis has made waves with a drug pipeline that includes one of the most talked - about experimental cancer therapies in recent years — a treatment called Kymriah that reconfigures the body's own immune cells to become aggressive blood - cancer killers.

It's the second approval for this pioneering approach to cancer treatment, which involves re-engineering patients» own immune cells to become cancer killers, after the FDA's approval of Novartis» Kymriah in August.

The biotech has been jockeying against main rivals Novartis and Juno to secure a first - to - market advantage with the groundbreaking new medical tech, which turns patients» immune cells into souped - up, re-engineered cancer killers that are then reintroduced into the body.

Disease: Sleep deprivation alters immune function, including the activity of the body's killer cells.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

Their randomized trial followed 161 patients treated either with a conventional immune - suppressing drug called methotrexate, or with methotrexate plus rituximab, the B - cell killer.

A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

Marta Monteiro and colleagues at the University of Lisbon, Portugal, studied mice protected from the animal equivalent of multiple sclerosis by natural killer T - cells (NKT), a class of white blood cell which helps to control the immune system.

Chronic HIV infection results in exhaustion of the immune system, a phenomenon characterized by dysfunctional HIV - specific killer T cells.

Their paper, which appears in Nature Communications, describes how an immune cell recruited to the tumor induces the programmed suicide, or apoptosis, of the killer T cells harnessed by many immunotherapies.

Interaction between the PD - 1 protein found on killer T cells and its binding partner PD - 1L is one hallmark of immune exhaustion, and interfering with this interaction a potential strategy to overcome it.

«NATURAL killer» cells form the front - line troops of the immune system.

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

Natural killer (NK) cells are lymphocytes involved in antimicrobial and antitumoral immune responses.

Wrangle explained that natural killer cells are the chief arm of the innate immune response.

Scientists have focused instead on the other branch of the immune system which marshals an army of specialised cells, such as killer T cells, against invaders.

Prof. Mandelboim and his research collaborators found that the NKp46 receptor present on Natural Killer or NK cells (an essential part of the immune system) play a critical role in the development of the disease in mice.

When a T cell detects one, it morphs into a fighting machine, zapping invaders with lethal chemicals, multiplying into an army of identical killers or signaling other immune - system troops to join the attack.

In essence, he says, weak T regs can mature into killer T cells that weed out other immune cells mounting attacks on healthy tissues.

This biosynthetic hybrid stimulates the development of weak T regs into killer T cells that destroy the immune cells directing the autoimmune attack.

Some types of innate immune cells, such as natural killer cells, can actually protect against tumor growth.

Some of the killer cells lose CXCR5 upon stimulation, but adding an immune regulatory molecule called TGF - beta can boost the CXCR5 levels.

These cells are a part of the body's immune system, but the CD4 cells can not fight the virus themselves; killer T - cells can.

This is an illustration showing interactions between components of the AH10 - 7 compound (yellow), an immune system antigen - presenting cell (gray), and an invariant natural killer T cell (green and blue) that spark activation of iNKT cells in «humanized» mice.

Natural killer cells (also known as NK cells, K cells, and killer cells) are a type of lymphocyte (a white blood cell) and a component of innate immune system.

So - called Natural killer (NK) cells are innate immune cells and responsible for the elimination of cancerous cells.

«It pointed us to the idea that although T cells and natural killer cells are important, maybe we're forgetting about a part of the immune system that is also really important and could help us achieve our goals of ultimately curing the tumors.»

They may also draw the attention of cells belonging to the innate immune system, such as natural killer cells, which can destroy tumor cells.

What's more, IL - 33 and the DNA vaccine augmented immunological responses in both CD4 helper T cells and CD8 killer T cells, with a large proportion of CD8 killer T cells demonstrating a further improvement in the ability of DNA vaccines to drive the immune system to kill tumor cells in animals.

Among those vaccinated, the investigators found significant increases of CD8 T - cells, the «killer» cells of the immune system, in cervical tissue.

MHC I & II molecules then bind the antigen and present it to different arms of the adaptive immune system, potentially mobilizing T cells, B cells and natural killer (NK) cells.

The immune system maintains a rich abundance of «natural killer» cells to confront microbial invaders, but as the body gains the upper hand in various infections it sometimes starts to produce even more of the cells.

Stress can cause changes in the function of the immune system, including reducing the number of natural killer cells that are known to battle cancer.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

Results showed that antibodies were able to bind to the cancer cells and recruited specific immune cells called natural killer cells, resulting in shrinkage of the tumor, significantly improving survival.

When the immune system stumbles upon an unknown foreign invader for the first time, it often takes days before lashing out with full force — a time during which T cells start dividing and differentiating into specialized cells, such as antibody - producing B cells and killer T cells.

«However, our results clearly show that natural killer cells can also carry out a long - lasting and effective immune reaction against the body's own pigmented cells, including malignant melanoma cells,» says Prof. Dr. Gunther Hartmann, Director of the Institute of Clinical Chemistry and Clinical Pharmacology of the University of Bonn.

10 Yale researchers have created plastic nanospheres that encapsulate proteins called cytokines, which stimulate the immune system's killer T - cells.

Once switched on, macrophages then decide whether immune cells including natural killer cells receive their marching orders,» explains Prof. Dr. Veit Hornung.

Innate immune effector cells, including natural killer cells, macrophages, and dendritic cells, have been shown to interact with cancers and inhibit their progression.

«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»