Sentences with phrase «immune mechanisms in»

(11, 12) Lowered immunity may also predispose children to SIBO by disrupting normal immune mechanisms in the intestine that keep bacterial counts in check.

Genotype - driven early phase trials, including exceptional responders and mechanisms of resistance and immune mechanisms in cancer and cellular therapy.

Prior to joining Helmsley, Garabet was an assistant professor in the Immunology Institute at the Icahn School of Medicine at Mount Sinai where he led a research team investigating the implication of innate immune mechanisms in IBD, Crohn's disease, colorectal cancer, and other gastrointestinal disorders.

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»

We investigated the relative importance of different immune mechanisms in limiting the spread of the intestinal microbiota.

Not exact matches

Immune oncology drugs use a mechanism to enable the immune system to «uncloak» hidden cancer cells in the body and then attack them.

CB - 1158 has single agent anti-tumor activity in syngeneic mouse tumor models that has been demonstrated to act through an immune mechanism.

if you're referring to classical Christianity, God created man immune to such destruction yet man then invited entropy into the system; so then God went all out in order to provide a mechanism of forgiveness so that even as beings of discord we could be compatible with eternity and preserved.

The immune system is actually an astonishing array of struc - tures and mechanisms de - signed to defend us from a wide variety of agents, in - cluding bacteria and viruses.

In addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanismIn addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanismin cellular defense mechanisms.

The three main conditions — celiac disease, gluten sensitivity, wheat allergy — are based on very different mechanisms in the immune system.

And yet the intricacies of that science — the precise mechanisms through which adrenal glands release glucocorticoids and immune cells send out cytokines — don't tell us much about how best to help children in trouble.

Different studies suggest that bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut immune cells.

«Scientists find potential mechanism for deadly, sepsis - induced secondary infection: Sepsis disrupts immune cell recruitment to infected skin in mice.»

There are a variety of mechanisms of immune resistance that operate in the tumor.

The advance, reported in Proceedings of the National Academy of Sciences (PNAS) journal, for the first time allows scientists to analyze how normal gut microbes and pathogenic bacteria contribute to immune responses, and to investigate IBD mechanisms in a controlled model that recapitulates human intestinal physiology.

What we're hoping, therefore, is that the new mechanisms we've discovered will help in the development of more targeted drugs, where existing immune - modulating drugs can also be of interest.»

Meanwhile, Van den Eynde and his team are already hard at work looking for the other novel mechanisms of immune suppression in their model.

The work was on the role of interleukin - 1 in the pathology of graft - versus - host disease (GVHD), the mechanism by which the new immune system, which a patient receives as a bone marrow transplant, attacks the patient's body following the transplantation.

The new discoveries show that bacteria toxins in some patients enable cancer cells to send off signals that obstruct and change the immune defence mechanism, which would otherwise fight the cancer cells.

Publishing online this week in Cell Host & Microbe, researchers at Johns Hopkins report the discovery of a key underlying immune mechanism that explains why to how our skin becomes inflamed from conditions such as atopic dermatitis, more commonly known as eczema.

Immunologists have long speculated that hormone changes early in pregnancy somehow alter the mother's immune system, but they couldn't pinpoint the mechanism.

«This discovery demonstrates the effect the gut microbiome has on the immune system and unearths a novel mechanism via which changes in the gut microbiome can increase the risk of autoimmune disorders.

In addition to using healthy cells to do their work for them, cancer cells also slowly destroy the skin's immune defence mechanism.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapieIn addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapiein cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

In a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assaulIn a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assaulin the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assault.

«The work provides new insight into mechanisms by which gut bacteria drive mucosal immune homeostasis,» added Jerrold R. Turner, MD, PhD, AGAF, editor - in - chief, Cellular and Molecular Gastroenterology and Hepatology.

The TSRI scientists discovered the fundamental mechanism of the S1PR1 receptor, developed the chemical tools to synthesize both agonists and antagonists of the receptor, discovered the role of the receptor in the immune system's «cytokine storm» in pandemic influenza, and investigated the role of the receptor in type 1 diabetes.

We're just now starting to discover how taste receptors in the upper respiratory tract are used to regulate the immune system against these infections, so defining the underlying mechanisms at play is critical to understanding these illnesses and developing new treatments.»

The underlying mechanism involves the activation of the immune system, resulting in local inflammation and proliferation of skin cells.

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T - cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests.

«It suggests there's a common mechanism in both species for susceptibility to tumor progression that may involve subversion of the host immune response.

These oppositional effects, the researchers say, suggest an evolutionary checks - and - balances mechanism to ensure that no single bacterium can overpower the others in its effects on the immune system.

«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.

Based on a defense mechanism in the immune system of bacteria that hunts and destroys invading viruses, CRISPR can locate and replace specific genes.

The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension, human LAD patients, is not because of a defect in the immune system's surveillance mechanism but because of the inflammation caused by the immune system's abnormal response to normal levels of bacteria in the gums.

This study is also the first to identify mechanisms by which gut bacteria triggers changes in the immune system that underlie MS progression.

HIV also has developed sophisticated mechanisms to dodge immune attack, shrouding its surface protein in sugars to hide vulnerable sites from antibodies and producing proteins that thwart production of other immune warriors.

«In addition, the results of this study provide new mechanisms for how abnormal pigmentation associated with some melanocytic nevi and melanomas might arise as a result of immune responses to the growths.»

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

The ability of these children to maintain an intact immune system in the face of ongoing viral replication and in the absence of antiretroviral therapy can provide us with new insights into hitherto unknown defense mechanisms, which could eventually benefit other HIV patients,» says Professor Oliver T. Keppler, Chair of Virology at the Pettenkofer Institute, and former head of the German Reference Center for Retroviruses in Frankfurt am Main.

Once they found that the OTULIN gene was abnormal in the sick children, they studied the immune pathway in order to understand the mechanisms of disease and to improve treatment of these patients.

Dr. Alan S. Cross, Professor of Medicine at University of Maryland School of Medicine, who was not involved in the research, shared his input: «This is a major conceptual breakthrough in our understanding of infection and immune disease mechanisms and may have implications for novel approaches to the treatment of other diseases characterized by cytokine storm.

«New hair growth mechanism discovered: Faulty immune cells may play role in alopecia, other forms of baldness.»

«Our study reveals a previously unknown mechanism that we might be able to block to make tumors «visible» again to attacking immune cells, perhaps in combination with other immunotherapies,» says Miller, also an associate professor in the Department of Cell Biology.

«Essential mechanism in immune response discovered.»

She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.

In this webinar we will discuss the latest advances in mouse models for cancer research and how they are being applied to help us understand the pathways and mechanisms involved in new immune therapieIn this webinar we will discuss the latest advances in mouse models for cancer research and how they are being applied to help us understand the pathways and mechanisms involved in new immune therapiein mouse models for cancer research and how they are being applied to help us understand the pathways and mechanisms involved in new immune therapiein new immune therapies.